This collection includes theses and dissertations from the Department of Biochemistry and Molecular Biology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.
Theses/Dissertations from 2023
Characterization of the immunoglobulin lambda chain across diverse human populations., William Gibson
Epitranscriptomic regulation in breast cancer and PCB-induced liver disease., Belinda Petri
Aurka inhibition-based combination therapy approaches in glioblastoma., Muge Sak
The interplay between lung adenocarcinoma, nutrient availability, and the microbiome., Alexis A. Vega
Theses/Dissertations from 2022
Applications of nuclear magnetic resonance spectroscopy: from drug discovery to protein structure and dynamics., Mark Vincent C. dela Cerna
Genomic tools and models for investigating the role of germline diversity in mouse antibody repertoire development., Justin T. Kos
Theses/Dissertations from 2021
Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload., Timothy N. Audam
Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis., Rumeysa Biyik-Sit
Genetic and functional analysis of rat mammary cancer susceptibility., Emily L Duderstadt
Metabolic-epigenetic regulation of macrophage polarization., Jordan T. Noe
Theses/Dissertations from 2020
The retinoblastoma protein mediates metabolic reprogramming in lung cancer., Lindsey R. Conroy
Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems., Robert Chandos Monsen
Theses/Dissertations from 2019
Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression., Stephanie Metcalf
Theses/Dissertations from 2018
Functional and structural impact of the loss of the leucine-rich repeat protein LRIT1 in the mouse retina., Catherine Ann Cobb
The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation., Jon David Faughn
Epidermal growth factor receptor (EGFR) inhibition by polychlorinated biphenyls contributes to non-alcoholic fatty liver disease (NAFLD)., Josiah Hardesty
Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy., Avisek Majumder
Alpha-amino methylation and acetylation are novel regulators of MYL9 function., Christopher David Nevitt
Cholesterol metabolism and statin effects on an FH class II LDL-receptor mutation., Linda Omer
Investigating the impact of NRMT1 cancer mutants on catalytic specificity and the DNA damage response., Kaitlyn Marie Shields
Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity., Alexis Avidan Vega
Theses/Dissertations from 2017
PCB-associated steatohepatitis and the role of nuclear receptors., Heather Brooke Clair
Role of MIR-29B-1 and MIR-29A in endocrine-resistant breast cancer., Penn Muluhngwi
Theses/Dissertations from 2016
Carnosine, a therapeutic potential for critical limb ischemic., Adjoa Agyemang Boakye
Glutathione s-transferase p in glucose homeostasis in mice., Shubha Ghosh Dastidar
Role of microRNA-21 in atherogenesis., Rihab Hamed-Berair
Molecular characterization of human papillomavirus in head and neck tumors., Sujita Khanal
Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides., Peter Joseph Kilfoil
ABIN1 in the pathogenesis of Glomerulonephritis and the novel polocyte-neutrophil proinflammatory axis., Erik Anderson Korte
Congenic and functional analysis of rat mammary cancer susceptibility., Saasha Le
A systems biology approach identifies a gene regulatory network in parotid acinar cell differentiation., Melissa Ann Metzler
The discovery of a novel, Ras-mediated NORE1A/PMLIV tumor suppressor complex., Jessica Mezzanotte Sharpe
Theses/Dissertations from 2015
Regulation of the retinoblastoma tumor suppressor by the novel Ras effector NORE1A., Thibaut François Barnoud
The Ras effector NORE1A forms a tumor suppressor complex with BRCA1., Nicholas C Nelson
Coordinate regulation of the WNT and Hippo pathways by the novel Ras effector NORE1A., Marvin Lee Schmidt Jr.
Role of c-Kit in the growth, migration and differentiation of human cardiac progenitor cells., Bathri Narayan Vajravelu
Theses/Dissertations from 2014
Augmentation of Ras-induced cell transformation : a new role for miR-200a in malignancy., Lindsey Erin Becker
Enzyme kinetics : 6-phosphofructo-2-kinase/2,6-bisphosphatase., Jennifer Clark
Troglitazone suppresses glutamine metabolism and tumor cell growth through a ppar-independent mechanism., Miriam R. Reynolds 1965-
Genetic and mechanistic analysis of rat mammary cancer susceptibility., Jennifer Sanders
Mechanisms of action and co-optive evolution for hypervariable courtship pheromones in plethodontid salamanders., Wilburn Beau Wilburn
Theses/Dissertations from 2013
Genetic mapping and mechanism of action of rat mammary carcinoma susceptibility quantitative trait locus Mcs1b., Aaron D. denDekker
Molecular bases of inherited bone marrow failures : Shwachman-Diamond syndrome and Diamond Blackfan anemia., Adrianna Lee Henson 1983-
6-phosphofructo-2-kinase inhibition induces autophagy as a survival mechanism., Alden Klarer
COUP-TFII and its interacting proteins in breast cancer and endocrine resistance., Lacey Morgan Litchfield
Constructing the rod bipolar cell signalplex using animal models of retinal dysfunction., Thomas Andrew Ray 1986-
Theses/Dissertations from 2012
The dynamic equilibrium of human telomeric G-quadruplexes., Robert Buscaglia
Co-option and adaptation of novel gene duplications for pheromone activity in a dusky salamander., Kari Anne Leichty 1987-
Dysregulation of microRNA expression in acquired endocrine-resistant breast cancer., Tissa Thomas Manavalan
Regulation of vascular smooth muscle cell phenotype., Joshua Kuimeta Salabei
Theses/Dissertations from 2011
Roles of VAMP3 in melanoma cell migration and integrin trafficking., Yaman Babi 1981-
Tumor-targeting aptamers for the treatment of prostate cancer., Enid W. Choi
Characterization of DNA-binding proteins as clinically relevant biomarkers of breast cancer behavior., Traci L. Kruer 1979-
Cytotoxicity and cellular response to alpha, beta-unsaturated aldehydes : role of aldehyde dehydrogenases., Ngome Llewellyn Makia
Structure-based design of inhibitors of CXCR4., Jason Bradley Meier 1980-
A statin-regulated microRNA represses c-Myc expression and function., Apana Agha L. Takwi 1980-
Theses/Dissertations from 2010
Topology and function of nyctalopin in yeast and in-vitro translation systems., Pasano Pasano Bojang
Determination of in silico rules for predicting small molecule binding behavior to nucleic acids in vitro., Patrick Andrew Holt
The role of MUC1 splice variants in dry eye and inflammation., Yoannis Imbert-Fernandez
Ribosome maturation in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome., Joseph Brady Moore 1981-
Nyctalopin is required for localization of the TRPM1 channel to the retinal depolarizing bipolar cell dendrites., Jillian Nydam Pearring
Theses/Dissertations from 2009
Mitochondrial targeting of the pro-apoptotic protein Bax : Role of the Bax carboxy-terminal tail., Stephanie Erin Brock 1980-
Theses/Dissertations from 2008
Lipid aldehydes are substrates and transcriptional regulators of cytochromes P450., Immaculate Amunom
Theses/Dissertations from 2007
Regulation of nuclear respiratory factor-1 expression by 17beta-estradiol : a new mechanism for coordinating mitochondrial gene expression., Kathleen AnnMarie Mattingly 1979-
Theses/Dissertations from 2006
Mechanistic studies of guanine-rich oligonucleotides., Allicia C. Girvan 1978-
Regulation of angiogenic factors by pituitary tumor transforming gene (PTTG) in tumorigenesis., Mohammad Tariq Malik
Theses/Dissertations from 2005
Defining the mechanisms of neutrophil exocytosis using proteomic techniques., George Lominadze 1978-
Theses/Dissertations from 2004
The transcriptional repressor protein growth factor independence-1B in T lymphopoiesis., Loretta L. Doan
DHEA action is mediated by multiple receptors and metabolites., Kristy K. Michael Miller
Theses/Dissertations from 2003
Regulation of Na,K-Atpase activity by tyrosine phosphorylation in lens cells., Larry Darko Bozulic 1974-
Theses/Dissertations from 1948
A biochemical investigation of cirrhosis., Mary Frank Beattie
Methemoglobin., Herbert Friedman
Theses/Dissertations from 1947
Studies on synthesis by enzymatic catalysis., Charles Henry Wabnitz 1916-2004
