Date on Master's Thesis/Doctoral Dissertation
Anatomical Sciences and Neurobiology
Magnuson, David Stuart
Spinal cord--Wounds and injuries--Research; Animal immobilization
Background: Spontaneous locomotor recovery in spinal rats has been attributed to animals moving freely in-cage. Environmental enrichment has been shown to increase in-cage movement and functional recovery subsequently. Anxiety has been shown to decrease overnight activity in rats. Methods: Rats were double-housed in medium cages (MC) or single-housed in tiny sized cages (TC). Slotted dividers allowed for partial isolation in TC. Overnight activity was monitored bi-weekly. The open field test and BBB’s were taken weekly. Gait analysis was performed at weeks six and eight. Results: MC showed higher overnight activity and improved gait overtime. No differences were found in BBB scores. Differences in anxiety began to show in the last few weeks of the study. Discussion: The opportunity for movement in MC led to these animals having higher in-cage activity and an improvement in gait. A more severe injury than anticipated perhaps caused low BBB scores. MC animals may have been anxious due to unwanted stressors.
Stipp, Kelsey Lee, "Effects of passive immobilization on locomotor recovery after spinal cord injury in adult rats." (2014). Electronic Theses and Dissertations. Paper 1388.