Date on Master's Thesis/Doctoral Dissertation


Document Type

Master's Thesis

Degree Name



Health and Sport Sciences

Degree Program

Exercise Physiology, MS

Committee Chair

Gerald Zavorsky

Committee Member

Carter, Kathy

Committee Member

Weiss, Edward

Committee Member

Folz, Rodney


Protandim; Oxidative stress; Athletes--Drug use


A double-blind placebo-controlled trial determined the long term effects of Protandim® supplementation on 5-km running performance, as well as on acute and long-term oxidative damage assessed by serum lipid peroxides (Thiobarbituric acid-reacting substances: TBARS). Thirty-eight subjects were placed into one of two groups: an experimental (675 mg/day Protandim®) or control group (675 mg/day corn starch). 5-km runs were performed at baseline and 88 (SD 4) days post-supplementation with samples taken immediately pre- and 10-min post 5-km run, as well as at rest ∼30 and ∼60 days during the supplementation period. There was ~25% week-to-week coefficient of variation of TBARS at baseline (rested, fasted). The runs did not acutely increase mean TBARS, nor was there a change in 5-km time or in mean serum TBARS (at rest, fasted) in either group after supplementation. In conclusion, it is unlikely that Protandim® improves 5-km performance, or that it reduces serum TBARS at rest.