Date on Master's Thesis/Doctoral Dissertation

5-2017

Document Type

Master's Thesis

Degree Name

M. Eng.

Cooperating University

University of Louisville

Department

Bioengineering

Degree Program

JB Speed School of Engineering

Committee Chair

Frieboes, Hermann

Committee Co-Chair (if applicable)

Steinbach-Rankins, Jill

Committee Member

Steinbach-Rankins, Jill

Committee Member

Altiparmak, Nihat

Author's Keywords

Cancer; tumor-associated macrophages; TIE-2 macrophages; mathematical modeling; computational simulation

Abstract

The most abundant immune cell types of the tumor microenvironment macrophages recruited there by tumor-eluted factors. The role of these immune cells in tumor progression, and the interplay between tumor and immune cells is an emerging field of research with potential for novel treatment strategies. Here, a TIE2 expressing macrophage (TEM) subtype is integrated into a virtual tumor model. Within the 2D microenvironment, the TEM will differentiate from an extravasated monocyte precursor, congregate around the abluminal side of the vasculature in response to a chemoattractant gradient, secrete cytokines which favor differentiation of a separate angiogenic macrophage subtype [1]. The effects of macrophage populations on tumor progression on angiogenic activity and tumor growth will be examined.

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