Date on Master's Thesis/Doctoral Dissertation
Epidemiology and Population Health
Taylor, Kira C.
Polypharmacy; Older people--Drug use; Older people--Mental health
Aging is associated with increased risk of chronic disease, comorbidities, and greater medication use. Polypharmacy, the concomitant use of 5 or more medications, has been associated with adverse health effects, and potentially cognitive decline. The proposed hypothesis is that polypharmacy increases the risk of cognitive decline in elderly people. Using longitudinal data from 572 participants from the New Mexico Aging Process Study cohort, the impact of polypharmacy on the Mini Mental State Examination (MMSE) scores and Mild Cognitive Impairment (MCI) was studied. The statistical analyses were performed using mixed linear regression multivariable models and generalized estimating equations, adjusting for important covariates. Polypharmacy was associated with a 0.11±0.09 decrease in MMSE scores (p-value=0.23) and an increased risk of MCI (odds ratio=1.95, 95% CI 0.40-9.43). The results suggest that polypharmacy may increase the rate of cognitive decline in elderly people. Larger studies in other populations are needed to support this hypothesis.
Gonzalez, Ximena A. Oyarzun, "Cognitive decline and polypharmacy in an elderly population." (2014). Electronic Theses and Dissertations. Paper 517.