Short Duration of Antibiotic Therapy in Hospitalized Patients with Community-Acquired Pneumonia: Results from the CAPO International Cohort Study

Authors

Alejandro Chirino Navarta, Servicio de Neumonología, Hospital Italiano, Mendoza, ArgentinaFollow
Paula Peyrani, Division of Infectious Diseases, Department of Medicine, University of Louisville School of Medicine, Louisville, KYFollow
Timothy L. Wiemken, Division of Infectious Diseases, Department of Medicine, University of Louisville School of Medicine, Louisville, KYFollow
Marcos I. Restrepo, South Texas Veterans Health Care System and University of Texas Health Science Center at San AntonioFollow
James D. Chalmers, Ninewells Hospital and Medical SchoolFollow
Carlos M. Luna, Hospital de Clinicas, Universidad de Buenos Aires, Buenos Aires, ArgentinaFollow
Francesco Blasi, Department of Pathophysiology and Transplantation, University of Milan, IRCCSFollow
Julio A. Ramirez, Division of Infectious Diseases, Department of Medicine, University of Louisville School of Medicine, Louisville, KYFollow
Stefano Aliberti, University of Milano-BicoccaFollow

Funder

The author(s) received no specific funding for this work.

Abstract

Introduction: Experts suggest a short duration of antibiotic therapy (DOT) in responding patients with community-acquired pneumonia (CAP). The aim of this study was to evaluate clinical outcomes after hospital discharge among patients treated with short-course antibiotic therapy (SCT) vs. long-course antibiotic therapy (LCT) for CAP.

Methods: A secondary analysis of the Community-Acquired Pneumonia Organization (CAPO) database from January 2007 to June 2013 was performed, including hospitalized CAP patients who reached clinical stability within 5 days. Two groups were identified: patients who were treated with antibiotic therapy for a total duration of 5 days or less (SCT Group) vs. longer than 5 days (LCT Group). Rehospitalization and mortality were evaluated at 30 days after discharge.

Results: 1,849 patients were enrolled (58% males; median age: 65 years), 179 (10%) were included in the SCT and 1,670 (90%) in the LTC group. Median DOT was 5 days in the SCT and 10 days in the LTC group, p

Conclusions: A duration of antibiotic therapy of ≤ 5 days does not adversely impact clinical outcomes at 30-days after discharge compared to >5 days in patients who reached early clinical stability.

DOI

10.18297/jri/vol1/iss3/6/

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Chirino Navarta, Alejandro; Peyrani, Paula; Wiemken, Timothy L.; Restrepo, Marcos I.; Chalmers, James D.; Luna, Carlos M.; Blasi, Francesco; Ramirez, Julio A.; and Aliberti, Stefano (2017) "Short Duration of Antibiotic Therapy in Hospitalized Patients with Community-Acquired Pneumonia: Results from the CAPO International Cohort Study," The University of Louisville Journal of Respiratory Infections: Vol. 1 : Iss. 3 , Article 6.
DOI: https://doi.org/10.18297/jri/vol1/iss3/6/
Available at: https://ir.library.louisville.edu/jri/vol1/iss3/6