This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please see: http://ir.library.louisville.edu/about.html.

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Theses/Dissertations from 2017

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Enhancing cell therapy for ischemic cardiomyopathy., Michael J. Book

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Neural coding of natural and synthetic speech., Allison Brown

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Spinal cord injury induced cardiac decline and the limitations of exercise., Kathryn Michele DeVeau

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Spontaneous vocal matching in mothers and their hearing impaired infants with cochlear implants : a quantitative analysis., Lydia Doggett

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The effects of moderate alcohol consumption and inflammation on the hepatic matrisome and the renal cortex proteome., Christine E. Dolin

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Targeting the glucose metabolism of myeloid-derived suppressor cells (MDSCs) to stimulate cancer immunity., Jaspreet Grewal

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Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy., Elizabeth Marie Hollis

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Identifying the signaling mechanisms of EGFR-mediated apoptosis., Nicole Marion Jackson

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Withaferin a synergistically enhances the effects of paclitaxel against lung cancer., Al Hassan Kyakulaga

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Role of MIR-29B-1 and MIR-29A in endocrine-resistant breast cancer., Penn Muluhngwi

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The interaction of homoserine lactones and paraoxonase 2 modulates cell death signaling and cell proliferation., Aaron Mackallan Neely

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Reversible silencing of spinal neurons unmasks a left-right coordination continuum., Amanda Marie Pocratsky

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Combating malignant melanoma with the multifaceted soy-dervied peptide lunasin., Christopher Paul Shidal

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Trunk and respiratory motor control in typically developing children and its implications in children with chronic spinal cord injury., Goutam Singh

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Characterization of a mutant oncolytic adenovirus and the role of jnk in enhancing virotherapy., Stephen L. Wechman

Theses/Dissertations from 2016

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Cardiovascular and hematopoietic responses to volatile benzene exposure., Wesley Tyler Abplanalp

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Identification of residual descending pathways after human spinal cord injury., Darryn A. Atkinson

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Role of phosphodiesterase-4 in alcohol-induced organ injury., Diana Veronica Avila

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Immune monitoring in recipients of combined living donor kidney and hematopoietic stem/facilitating cell transplants., Mark DeWayne Badder

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SA-4-1BBL as a modulator of innate, adaptive, and regulatory immunity : implications for cancer prevention and treatment., Hampartsoum Barsoumian

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Establishing a clinically relevant mouse model of human AML to test novel transmethylation inhibitors., Aditya Barve

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Carnosine, a therapeutic potential for critical limb ischemic., Adjoa Agyemang Boakye

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The role of the MiR-200 family on the tumor suppressor RASSF2 and the effect on MAPK pathway activity in colorectal cancer., Jane V. Carter

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Acrolein is a critical mediator of alcohol-induced liver and intestinal injury in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Identification of host factors required for Yersinia pestis macrophage intracellular survival and their impact on vacuole maturation, acidification and trafficking., Michael Graylin Connor

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The role of O-GlcNAcase during heart failure., Sujith Dassanayaka

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Impact of epigallocatechin-3-gallate (EGCG), a broad-spectrum anti-inflammatory, in controlling intestinal factors contributing to inflammatory bowel disease., Gerald Wayne Dryden, Jr.

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Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-mediated hypertension., Anastasia Familtseva

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Air pollution, pulmonary oxidative stress, and the endothelin system in the development of cardiovascular injury., Jordan B. Finch

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Microbiota activated CD103+ DCS stemming from oral microbiota adaptation specifically drive γδT17 proliferation and activation., Christopher Jay Fleming

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In vivo monitoring of therapeutic efficacy and virulence profile by bioluminescent Klebsiella pneumoniae., Ramy Ameen Fodah

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The role and regulation of inhibitor of Kappa B Kinase in the impaired monocyte response., Norman James Galbraith

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Glutathione s-transferase p in glucose homeostasis in mice., Shubha Ghosh Dastidar

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Isolation of EGFR-containing early endosomes., Julie A. Gosney

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Characterization of the role of the Burkholderia pseudomallei type 3 secretion system using in vivo imaging., Maria Gabriela Gutierrez

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The role of the nucleolus in neurodegeneration., Justin Lauren Hallgren

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Role of microRNA-21 in atherogenesis., Rihab Hamed-Berair

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Evaluating cardiovascular dysfunction during increased activity and exercise rehabilitation following incomplete thoracic spinal cord injury in the adult rat., Kathryn A. Harman

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Pro-inflammatory cytokines promote viral replication and cell cycle mediators in arenavirus-induced hepatitis., Gretchen E. Holz

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MicroRNA-186 and metastatic prostate cancer., Dominique Zilpha Jones

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Cell-based therapies for ischemic cardiomyopathy : investigations of intramyocardial retention and safety of high dose intracoronary delivery of c-kit positive cardiac progenitor cells, and therapeutic utility of a novel population of cardiac mesenchymal stem cells expressing stage-specific embryonic antigen-3 (SSEA-3)., Matthew C. L. Keith

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Molecular characterization of human papillomavirus in head and neck tumors., Sujita Khanal

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Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides., Peter Joseph Kilfoil

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ABIN1 in the pathogenesis of Glomerulonephritis and the novel polocyte-neutrophil proinflammatory axis., Erik Anderson Korte

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Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat., Sarah Krupp

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Vinyl chloride-diet interactions in liver disease : potential roles of autophagy and energy management., Anna L. Lang

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Congenic and functional analysis of rat mammary cancer susceptibility., Saasha Le

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TNF-like weak inducer of apoptosis (TWEAK) : not so weak after all., Joseph Dekward McMillan IV

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A systems biology approach identifies a gene regulatory network in parotid acinar cell differentiation., Melissa Ann Metzler

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Modulation of cell death signaling and cell proliferation by the interaction of homoserine lactones and Paraoxonase 2., Aaron Mackallan Neely

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Transient receptor potential cation channel, subfamilies V, member 1 (TRPV1) and M, member 1 (TRPM1) contribute to neural signaling in mouse retina., Jennifer Noel

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The influence of miR-99a on mTOR signaling regulation in colorectal cancer cell lines., Jonathan Rice

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Developing a more clinically-relevant mouse model of cisplatin-induced nephrotoxicity., Cierra N. Sharp

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The discovery of a novel, Ras-mediated NORE1A/PMLIV tumor suppressor complex., Jessica Mezzanotte Sharpe

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Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections., Kevin Tyo

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The role of nicotine, a7 nicotinic acetylcholine receptors and extracellular matrix remodeling in pulmonary fibrosis., Glenn Ward Vicary

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The effects of direct peritoneal resuscitation on leukocyte infiltration after acute brain death., Jessica Lee Weaver

Theses/Dissertations from 2015

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Immunomodulation of myeloid-derived suppressor cells by particulate b-glucan in cancer., Sabrin Husein Albeituni

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Characterizing the neuropeptide pathways between the forebrain and the pons., Ali Al-Magableh

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Promoting differentiation and survival of human c-kit+ cardiac progenitor cells ex vivo., Tareq Al-Maqtari

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A plant-made cholera toxin B subunit enhances mucosal wound healing and protects against ulcerative colitis and colon cancer., Keegan J Baldauf

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Regulation of the retinoblastoma tumor suppressor by the novel Ras effector NORE1A., Thibaut François Barnoud

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Critical insights into the pathogenesis of clinical isolates of pandemic influenza A(H1N1) 2009 virus in mouse and ferret models., Jeremy V. Camp 1980-

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Metabolomics of transformed MDA-MB-231 cell lines expressing different levels of human arylamine N-acetyltransferase 1 (NAT1)., Samantha Marie Carlisle

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Chemoattractant receptors BLT1 and CXCR3 regulate anti-tumor immunity by facilitating CD8+ T cell migration to tumors., Zinal S. Chheda

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Cardiovascular regulation and effects of respiratory motor training in patients with chronic spinal cord injury., Bonnie Legg Ditterline

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Mechanisms and intervention strategies for alcohol and HIV-antiretroviral therapy-induced liver injury., Hridgandh Donde

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Suramin protects from cisplatin-induced acute kidney injury., Tess Dupre

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Early host response and immune signaling to 2009 pandemic influenza A (H1N1) viruses in primary cell culture models., Rachael Lask Gerlach

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Exploring the roles of host and tumor cell α4 and α7 nicotinic acetylcholine receptors in lung cancer., John Caleb Greenwell, 1987-

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Characterization of the innate response to the RagB protein of Porphyromonas gingivalis., Justin Hutcherson

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The regulation and mechanisms of EGFR-mediated apoptosis in MDA-MB-468 cells., Nicole Marion Jackson

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Combination treatment with conjugated linoleic acid and nitrite protects against myocaridal infarction., Natia Qipshidze Kelm

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Searching for novel ligands for the cannabinoid and related receptors., Pritesh Prakash Kumar, 1986-

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Regulation of receptor tyrosine kinases by Ubiquilin1., Zimple Kurlawala

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The Ras effector NORE1A forms a tumor suppressor complex with BRCA1., Nicholas C Nelson

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Identifying Hepatocellular Carcinoma (HCC) cells with cancer stem cell-like properties., Harshulkumar M. Pandit

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Chronic ethanol exposure sensitizes the lung in a mouse model of endotoxemia-induced acute lung injury : potential role of plasminogen activator inhibitor-1., Lauren G. Poole

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Development of a vascularized, induced pluripotent stem cell-derived liver-tissue mimic for therapeutic applications., Venkat Madhav Ramakrishnan

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Coordinate regulation of the WNT and Hippo pathways by the novel Ras effector NORE1A., Marvin Lee Schmidt Jr., 1980-

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Role of c-Kit in the growth, migration and differentiation of human cardiac progenitor cells., Bathri Narayan Vajravelu

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Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury., Patrick Van Hoose

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Improved oncolytic virotherapy by increasing virus spread within tumors., Stephen Wechman

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Functional characterization of Aggregatibacter actinomycetemcomitans QSEBC : a bacterial adrengeric receptor and global regulator of virulence., Whitney Weigel

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Exercise mitigates the effects of hyperhomocysteinemia on adverse skeletal muscle remodeling., Lee Winchester

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Circulating angiogenic stem cells in diabetes., Nagma Zafar

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Glycine receptor alpha subunit (GlyRa) specific inhibition contributes to ganglion cell signaling in mouse retina., Chi Zhang

Theses/Dissertations from 2014

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The role of pesticides in non-alcoholic fatty liver disease (NAFLD)., Laila Al-Eryani 1986-

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Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis., Diana Veronica Avila

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MiRNA-21 has anti-inflammatory effects in the macrophage response to peritonitis., Rebecca Elise Barnett 1982-

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Evaluation of the safety and pharmacokinetic profile of the broad spectrum antiviral lectin Griffithsin., Christopher Lynn Barton 1976-

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Augmentation of Ras-induced cell transformation : a new role for miR-200a in malignancy., Lindsey Erin Becker 1986-

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Modulation of host polyubiquitination by the ankb f-box protein of Legionella pneumophila., William M. Bruckert

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Pathogenic role of acrolein in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Enzyme kinetics : 6-phosphofructo-2-kinase/2,6-bisphosphatase., Jennifer Clark

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SA-4-1BBL as a platform to develop adjuvant systems for prophylactic and therapeutic vaccines., Gunes Dinc 1984-

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Study of novel nanoparticle transport and drug release for cancer treatment., Christopher Gene England 1988-

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Neurodegeneration-associated instability of ribosomal DNA., Justin Lauren Hallgren 1981-

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The effect of spinal cord injury on vagal afferents., April N. Herrity

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Signaling mechanisms in regenerative myogenesis., Sajedah M. Hindi 1986-