This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please see: http://ir.library.louisville.edu/about.html.

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Theses/Dissertations from 2016

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Cardiovascular and hematopoietic responses to volatile benzene exposure., Wesley Tyler Abplanalp

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Role of phosphodiesterase-4 in alcohol-induced organ injury., Diana Veronica Avila

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SA-4-1BBL as a modulator of innate, adaptive, and regulatory immunity : implications for cancer prevention and treatment., Hampartsoum Barsoumian

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Carnosine, a therapeutic potential for critical limb ischemic., Adjoa Agyemang Boakye

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Acrolein is a critical mediator of alcohol-induced liver and intestinal injury in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Identification of host factors required for Yersinia pestis macrophage intracellular survival and their impact on vacuole maturation, acidification and trafficking., Michael Graylin Connor

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The role of O-GlcNAcase during heart failure., Sujith Dassanayaka

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Impact of epigallocatechin-3-gallate (EGCG), a broad-spectrum anti-inflammatory, in controlling intestinal factors contributing to inflammatory bowel disease., Gerald Wayne Dryden, Jr.

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Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-mediated hypertension., Anastasia Familtseva

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Air pollution, pulmonary oxidative stress, and the endothelin system in the development of cardiovascular injury., Jordan B. Finch

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Microbiota activated CD103+ DCS stemming from oral microbiota adaptation specifically drive γδT17 proliferation and activation., Christopher Jay Fleming

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In vivo monitoring of therapeutic efficacy and virulence profile by bioluminescent Klebsiella pneumoniae., Ramy Ameen Fodah

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Isolation of EGFR-containing early endosomes., Julie A. Gosney

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Characterization of the role of the Burkholderia pseudomallei type 3 secretion system using in vivo imaging., Maria Gabriela Gutierrez

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The role of the nucleolus in neurodegeneration., Justin Lauren Hallgren

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Role of microRNA-21 in atherogenesis., Rihab Hamed-Berair

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MicroRNA-186 and metastatic prostate cancer., Dominique Zilpha Jones

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Cell-based therapies for ischemic cardiomyopathy : investigations of intramyocardial retention and safety of high dose intracoronary delivery of c-kit positive cardiac progenitor cells, and therapeutic utility of a novel population of cardiac mesenchymal stem cells expressing stage-specific embryonic antigen-3 (SSEA-3)., Matthew C. L. Keith

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Molecular characterization of human papillomavirus in head and neck tumors., Sujita Khanal

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Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides., Peter Joseph Kilfoil

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ABIN1 in the pathogenesis of Glomerulonephritis and the novel polocyte-neutrophil proinflammatory axis., Erik Anderson Korte

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Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat., Sarah Krupp

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Vinyl chloride-diet interactions in liver disease : potential roles of autophagy and energy management., Anna L. Lang

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Congenic and functional analysis of rat mammary cancer susceptibility., Saasha Le

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A systems biology approach identifies a gene regulatory network in parotid acinar cell differentiation., Melissa Ann Metzler

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Modulation of cell death signaling and cell proliferation by the interaction of homoserine lactones and Paraoxonase 2., Aaron Mackallan Neely

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The influence of miR-99a on mTOR signaling regulation in colorectal cancer cell lines., Jonathan Rice

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Developing a more clinically-relevant mouse model of cisplatin-induced nephrotoxicity., Cierra N. Sharp

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The discovery of a novel, Ras-mediated NORE1A/PMLIV tumor suppressor complex., Jessica Mezzanotte Sharpe

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Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections., Kevin Tyo

Theses/Dissertations from 2015

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Immunomodulation of myeloid-derived suppressor cells by particulate b-glucan in cancer., Sabrin Husein Albeituni

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Characterizing the neuropeptide pathways between the forebrain and the pons., Ali Al-Magableh

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Promoting differentiation and survival of human c-kit+ cardiac progenitor cells ex vivo., Tareq Al-Maqtari

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A plant-made cholera toxin B subunit enhances mucosal wound healing and protects against ulcerative colitis and colon cancer., Keegan J Baldauf

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Regulation of the retinoblastoma tumor suppressor by the novel Ras effector NORE1A., Thibaut François Barnoud

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Critical insights into the pathogenesis of clinical isolates of pandemic influenza A(H1N1) 2009 virus in mouse and ferret models., Jeremy V. Camp 1980-

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Metabolomics of transformed MDA-MB-231 cell lines expressing different levels of human arylamine N-acetyltransferase 1 (NAT1)., Samantha Marie Carlisle

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Chemoattractant receptors BLT1 and CXCR3 regulate anti-tumor immunity by facilitating CD8+ T cell migration to tumors., Zinal S. Chheda

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Cardiovascular regulation and effects of respiratory motor training in patients with chronic spinal cord injury., Bonnie Legg Ditterline

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Mechanisms and intervention strategies for alcohol and HIV-antiretroviral therapy-induced liver injury., Hridgandh Donde

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Suramin protects from cisplatin-induced acute kidney injury., Tess Dupre

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Early host response and immune signaling to 2009 pandemic influenza A (H1N1) viruses in primary cell culture models., Rachael Lask Gerlach

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Exploring the roles of host and tumor cell α4 and α7 nicotinic acetylcholine receptors in lung cancer., John Caleb Greenwell, 1987-

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Characterization of the innate response to the RagB protein of Porphyromonas gingivalis., Justin Hutcherson

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The regulation and mechanisms of EGFR-mediated apoptosis in MDA-MB-468 cells., Nicole Marion Jackson

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Combination treatment with conjugated linoleic acid and nitrite protects against myocaridal infarction., Natia Qipshidze Kelm

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Searching for novel ligands for the cannabinoid and related receptors., Pritesh Prakash Kumar, 1986-

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Regulation of receptor tyrosine kinases by Ubiquilin1., Zimple Kurlawala

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The Ras effector NORE1A forms a tumor suppressor complex with BRCA1., Nicholas C Nelson

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Identifying Hepatocellular Carcinoma (HCC) cells with cancer stem cell-like properties., Harshulkumar M. Pandit

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Chronic ethanol exposure sensitizes the lung in a mouse model of endotoxemia-induced acute lung injury : potential role of plasminogen activator inhibitor-1., Lauren G. Poole

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Development of a vascularized, induced pluripotent stem cell-derived liver-tissue mimic for therapeutic applications., Venkat Madhav Ramakrishnan

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Coordinate regulation of the WNT and Hippo pathways by the novel Ras effector NORE1A., Marvin Lee Schmidt Jr., 1980-

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Role of c-Kit in the growth, migration and differentiation of human cardiac progenitor cells., Bathri Narayan Vajravelu

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Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury., Patrick Van Hoose

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Improved oncolytic virotherapy by increasing virus spread within tumors., Stephen Wechman

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Functional characterization of Aggregatibacter actinomycetemcomitans QSEBC : a bacterial adrengeric receptor and global regulator of virulence., Whitney Weigel

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Exercise mitigates the effects of hyperhomocysteinemia on adverse skeletal muscle remodeling., Lee Winchester

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Circulating angiogenic stem cells in diabetes., Nagma Zafar

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Glycine receptor alpha subunit (GlyRa) specific inhibition contributes to ganglion cell signaling in mouse retina., Chi Zhang

Theses/Dissertations from 2014

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The role of pesticides in non-alcoholic fatty liver disease (NAFLD)., Laila Al-Eryani 1986-

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Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis., Diana Veronica Avila

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MiRNA-21 has anti-inflammatory effects in the macrophage response to peritonitis., Rebecca Elise Barnett 1982-

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Evaluation of the safety and pharmacokinetic profile of the broad spectrum antiviral lectin Griffithsin., Christopher Lynn Barton 1976-

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Augmentation of Ras-induced cell transformation : a new role for miR-200a in malignancy., Lindsey Erin Becker 1986-

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Modulation of host polyubiquitination by the ankb f-box protein of Legionella pneumophila., William M. Bruckert

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Pathogenic role of acrolein in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Enzyme kinetics : 6-phosphofructo-2-kinase/2,6-bisphosphatase., Jennifer Clark

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SA-4-1BBL as a platform to develop adjuvant systems for prophylactic and therapeutic vaccines., Gunes Dinc 1984-

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Study of novel nanoparticle transport and drug release for cancer treatment., Christopher Gene England 1988-

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Neurodegeneration-associated instability of ribosomal DNA., Justin Lauren Hallgren 1981-

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The effect of spinal cord injury on vagal afferents., April N. Herrity

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Signaling mechanisms in regenerative myogenesis., Sajedah M. Hindi 1986-

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The role of stem cells in adipose tissue remodeling., Candice ReShay Holden 1988-

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The impact of inflammatory and immune response-related genetic variants on prostate cancer risk among men of African descent., Dominique Zilpha Jones

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A mechanism for trif adaptor-biased signaling by toll-like receptor 4., Joseph Peterson Kolb

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Functional implications of demyelination and the molecular control of remyelination in the adult mouse., Nicholas John Kuypers 1980-

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Biophysical and computational investigations into G-quadruplex structural polymorphism and interaction with small molecules., Huy Tuan Le 1986-

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Extracellular matrix proteins and the liver-lung axis in disease., Veronica L. Massey

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Development of models for the study of the molecular mechanisms of host restriction and adaptation of hantaviruses., Ryan Carroll McAllister 1988-

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BDNF maintains adult taste innervation and is required for taste nerve regeneration after injury., Lingbin Meng

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IL-12 induced modulation of tumor derived myeloid cell inflammatory responsiveness., Courtney Jetun Mitchell

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Post-transcriptional regulation of the Type IIA sodium-phosphate cotransporter by parathyroid hormone., Rebecca Dale Murray

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Epigenetic modifications associated with aortic remodeling in hyperhomocysteinemia., Nithya Narayanan

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Myocyte-specific overexpression of stromal cell-derived Factor 1 facilitates cardiac regeneration and improves myocardial function after infarction in mice., Detlef Ernst-Rudolf Obal

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Effects of step training on the kidneys following spinal cord injury in rats., Pradeepa Poudyal

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Bone strength and architecture : pharmacological targeting of CaMKK2 as a method for enhancing bone quality., Zachary James Pritchard 1988-

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Troglitazone suppresses glutamine metabolism and tumor cell growth through a ppar-independent mechanism., Miriam R. Reynolds 1965-

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Modulation of the ovarian cancer humoral response by tumor-derived exosomes., Carolyn Denise Roberson

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Genetic and mechanistic analysis of rat mammary cancer susceptibility., Jennifer Sanders

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The anti-obesogenic effects of nitric oxide., Brian Edward Sansbury 1985-

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Craniodental anatomy of a new late cretaceous multituberculate mammal from Udan Sayr, Mongolia., Amir Subhash Sheth 1988-

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Lunasin reduces the melanoma stem cell population in vitro and inhibits tumor proliferation in vivo., Christopher Paul Shidal

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Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death., Melissa Skibba 1990-

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Building a metabolic bridge between glycolysis and sphingolipid biosynthesis : implications in cancer., Morgan L. Stathem

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Inducible tumor difference between rapid and slow rat Nat2 congenic Fischer 344 rats administered methyl-nitrosourea., Marcus W. Stepp

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Effects of passive immobilization on locomotor recovery after spinal cord injury in adult rats., Kelsey Lee Stipp

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Evaluating the effects of aroclor 1260 in non-alcoholic fatty liver disease : the role of xenobiotic receptors., Banrida Wahlang

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Mechanisms of action and co-optive evolution for hypervariable courtship pheromones in plethodontid salamanders., Wilburn Beau Wilburn 1986-

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Inflammation-resolving lipid mediators promote revascularization to enhance wound healing., Michael Jingyuan Zhang