This collection includes theses and dissertations from the Department of Pharmacology and Toxicology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please see: http://ir.library.louisville.edu/about.html.

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Theses/Dissertations from 2016

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Role of phosphodiesterase-4 in alcohol-induced organ injury., Diana Veronica Avila

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Establishing a clinically relevant mouse model of human AML to test novel transmethylation inhibitors., Aditya Barve

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Acrolein is a critical mediator of alcohol-induced liver and intestinal injury in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Air pollution, pulmonary oxidative stress, and the endothelin system in the development of cardiovascular injury., Jordan B. Finch

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Isolation of EGFR-containing early endosomes., Julie A. Gosney

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The role of the nucleolus in neurodegeneration., Justin Lauren Hallgren

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Pro-inflammatory cytokines promote viral replication and cell cycle mediators in arenavirus-induced hepatitis., Gretchen E. Holz

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MicroRNA-186 and metastatic prostate cancer., Dominique Zilpha Jones

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Vinyl chloride-diet interactions in liver disease : potential roles of autophagy and energy management., Anna L. Lang

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Modulation of cell death signaling and cell proliferation by the interaction of homoserine lactones and Paraoxonase 2., Aaron Mackallan Neely

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Developing a more clinically-relevant mouse model of cisplatin-induced nephrotoxicity., Cierra N. Sharp

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Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections., Kevin Tyo

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The role of nicotine, a7 nicotinic acetylcholine receptors and extracellular matrix remodeling in pulmonary fibrosis., Glenn Ward Vicary

Theses/Dissertations from 2015

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Promoting differentiation and survival of human c-kit+ cardiac progenitor cells ex vivo., Tareq Al-Maqtari

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A plant-made cholera toxin B subunit enhances mucosal wound healing and protects against ulcerative colitis and colon cancer., Keegan J Baldauf

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Metabolomics of transformed MDA-MB-231 cell lines expressing different levels of human arylamine N-acetyltransferase 1 (NAT1)., Samantha Marie Carlisle

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Mechanisms and intervention strategies for alcohol and HIV-antiretroviral therapy-induced liver injury., Hridgandh Donde

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Suramin protects from cisplatin-induced acute kidney injury., Tess Dupre

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Exploring the roles of host and tumor cell α4 and α7 nicotinic acetylcholine receptors in lung cancer., John Caleb Greenwell, 1987-

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The regulation and mechanisms of EGFR-mediated apoptosis in MDA-MB-468 cells., Nicole Marion Jackson

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Searching for novel ligands for the cannabinoid and related receptors., Pritesh Prakash Kumar, 1986-

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Regulation of receptor tyrosine kinases by Ubiquilin1., Zimple Kurlawala

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Identifying Hepatocellular Carcinoma (HCC) cells with cancer stem cell-like properties., Harshulkumar M. Pandit

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Chronic ethanol exposure sensitizes the lung in a mouse model of endotoxemia-induced acute lung injury : potential role of plasminogen activator inhibitor-1., Lauren G. Poole

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Improved oncolytic virotherapy by increasing virus spread within tumors., Stephen Wechman

Theses/Dissertations from 2014

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The role of pesticides in non-alcoholic fatty liver disease (NAFLD)., Laila Al-Eryani 1986-

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Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis., Diana Veronica Avila

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Evaluation of the safety and pharmacokinetic profile of the broad spectrum antiviral lectin Griffithsin., Christopher Lynn Barton 1976-

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Pathogenic role of acrolein in alcoholic liver disease., Wei-Yang (Jeremy) Chen 1980-

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Study of novel nanoparticle transport and drug release for cancer treatment., Christopher Gene England 1988-

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Neurodegeneration-associated instability of ribosomal DNA., Justin Lauren Hallgren 1981-

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The impact of inflammatory and immune response-related genetic variants on prostate cancer risk among men of African descent., Dominique Zilpha Jones

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Extracellular matrix proteins and the liver-lung axis in disease., Veronica L. Massey

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Development of models for the study of the molecular mechanisms of host restriction and adaptation of hantaviruses., Ryan Carroll McAllister 1988-

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Bone strength and architecture : pharmacological targeting of CaMKK2 as a method for enhancing bone quality., Zachary James Pritchard 1988-

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Lunasin reduces the melanoma stem cell population in vitro and inhibits tumor proliferation in vivo., Christopher Paul Shidal

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Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death., Melissa Skibba 1990-

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Building a metabolic bridge between glycolysis and sphingolipid biosynthesis : implications in cancer., Morgan L. Stathem

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Inducible tumor difference between rapid and slow rat Nat2 congenic Fischer 344 rats administered methyl-nitrosourea., Marcus W. Stepp

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Evaluating the effects of aroclor 1260 in non-alcoholic fatty liver disease : the role of xenobiotic receptors., Banrida Wahlang

Theses/Dissertations from 2013

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Probing the anti-cancer mechanism of selenite : a metabolic approach., Alex Belshoff

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Cyclin E induction and oncolytic replication of E1b-deleted adenoviruses., Pei-Hsin Cheng, 1983-

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Role of ethanol as a cofactor in HAART induced hepatic steatosis and injury., Hridgandh Donde

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Enhanced penetration of lipid functionalized nanoparticles in 3D cell cultures., Christopher Gene England 1988-

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Preclinical safety assessment of Griffithsin-based vaginal microbicides., Amanda Lasnik

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Olanzapine-induced liver injury : direct metabolic effects, exacerbation by high-fat diet, and protection with sulforaphane., Robin H. Schmidt 1984-

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The role of a7 nicotine acetylcholine receptors in lung injury and repair., Glenn Vicary

Theses/Dissertations from 2012

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Approaches in the treatment of Parkinson's disease : a focus on stem cell-based therapies., Tareq Al-maqtari 1979-

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Acetaldehyde dehydrogenase 2 (ALDH2) activation protects hepatocytes from mitochondrial damage and death caused by 4-hydroxynonenal., Keegan J. Baldauf 1982-

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The role of endogenous Bcl-xL in regulation of apoptotic signaling pathways., Colins Ogwandi Eno 1982-

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Idiopathic pulmonary fibrosis : diagnosis, management, and the search for a cure., Daniel Fioret

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Role of human arylamine N-acetyltransferase in carcinogen metabolism and human breast cancer progression., Carmine Simone Leggett

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Integrin inhibitor cycloRGDfV blunts enhanced LPS-induced liver injury caused by ethanol in mice., Veronica L. Massey

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Polychlorinated biphenyl 153 exacerbates nonalcoholic fatty liver disease in C57BL/6 mice., Banrida Wahlang 1986-

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Structure-activity relationship model for estrogen receptor ligands., Huihui Wu 1979-

Theses/Dissertations from 2011

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Roles of 5HT1A receptor in CNS neurogenesis and ADAM21 in spinal cord injury., Sheila Ann Arnold 1981-

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Development and evaluation of polymeric implants of curcumin for enhanced chemopreventive activity., Shyam Sunder Bansal

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Profile of systemic treatment with the antiviral lectin Griffithsin in guinea pigs., Christopher Lynn Barton 1976-

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Mechanistic insights into copper-induced regression of heart hypertrophy., Katherine Bourcy

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Prevention and treatment of lung cancer by green tea polyphenols., Pengxiao Cao

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Adenovirus-induced cyclin E activates CDK2 for virus replication., Pei-Hsin Cheng 1983-

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Searching for novel ligands for the cannabinoid and related receptors., Pritesh Prakash Kumar 1986-

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Role of HDACs and SAM in interferon-alpha signaling and epigenetic regulation of anti-HCV gene expression., Stephanie A. Mathews

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Functional analysis of N-acetyltransferase (NAT1*14B and NAT1*10) in complete NATb and NATa mRNA., Lori Michele Millner

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Mitigating cisplatin resistance in ovarian cancer., Clarisse S. Muenyi

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Arsenic-induced developmental changes in the liver and adult cardiovascular disease., Ntube Nini Olive Ngalame

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Pharmacists as mid-level healthcare providers and the clinical results of a pharmacist-led diabetes disease management program., Benjamin Maurice Risner 1983-

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The role of curcumin in response to BPDE-induced DNA damage in human lung epithelial cells., Erica Nicole Rogers

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Sulforaphane prevents acetaminophen-induced hepatic injury in mice., Robin H. Schmidt 1984-

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DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage., Lindsey Jay Stallons 1983-

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Cardiac abnormalities after transaortic constriction are worsened by changing glucose metabolism and benefited by repair of mitochondrial DNA., Jianxun Wang 1969-

Theses/Dissertations from 2010

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The role of genetic and environmental oxidative stress factors in prostate cancer., Nicole A. Lavender

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Functional effects of CYP1A2, NAT1, and NAT2 genetic variants in nucleotide excision repair-deficient human fibroblasts : implications for toxicological risk from environmental arylamines., Carmine Simone Leggett

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Curcumin reactivates epigenetically silenced tumor suppressor gene tissue factor pathway inhibitor-2 in hepatocellular carcinoma cells., Akshata Moghe 1983-

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Cigarette smoke, DNA damage and repair in human cervical and vaginal cells in vitro and ex vivo., Afsoon Moktar

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Adriamycin nephrotoxicity is reduced by metallothionein over-expression and kidney gene expression is modified by diabetes in the OVE26 diabetic model., Lu Yang

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Arsenic in drinking water causes gene expression changes in the liver related to inflammation and metabolic dysfunction and accelerates atherosclerosis in ApoE-/-mice, Matthew R. Zajack

Theses/Dissertations from 2009

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The role of PKC-epsilon in models of alcohol- and toxin-induced liver disease., J. Phillip Kaiser 1981-

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Mechanisms mediated by CXCL12 signaling through CXCR4 and CXCR7 in breast cancer., LaSharon Denise Mosley

Theses/Dissertations from 2008

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The role of Hsp90 in PC-12 cell survival., Christina Blume Clark

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The use of the reducing agent N-(2-Mercaptopropionyl)glycine to detoxify oxidized lipids in atherosclerotic lesions., Nason P. Schooler 1974-

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Mutagenic and tumor suppressor functions of DNA polymerase iota in mammalian cells., Lindsey Jay Stallons 1983-

Theses/Dissertations from 2007

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Participation of mouse DNA polymerases iota, eta, and rev1 in translesion synthesis of carcinogen induced DNA adducts and carcinogenesis., Chad Aaron Dumstorf 1977-

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The changes of fructos-2,6-bisphosphate level in transgenic mice causing cardiomyopathy., Jianxun Wang 1969-

Theses/Dissertations from 2006

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Mechanism of 4-Hydroxynonenal induced toxicity in Jurkat CD4+ T lymphocytes., Wei Yuan Chang

Theses/Dissertations from 2005

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Investigations of N-acetyltransferases in human hepatocytes and rat models., Jason Matthew Walraven

Theses/Dissertations from 2004

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The role of nuclear factors of activated T-cells (NFAT) in neuronal death., Agata M. Habas 1976-

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The roles of pancreatic beta cell antioxidants in islet transplantation and type 1 diabetes., Xiaoyan Li

Theses/Dissertations from 2003

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Studies of the effects of pancreatic beta cell antioxidant transgenes on experimental models of diabetes., Hainan Chen

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Oxygen toxicity and mitochondrial metabolism., Jian Li 1974-

Theses/Dissertations from 2002

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Metallothionein overexpression prolongs grafts survival in the early phase of pancreatic islet transplantation., Xiaoyan Li

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Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy., Xia Shen 1976-

Theses/Dissertations from 1945

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Studies on spinal anesthesia., Frederic E. Shaffer

Theses/Dissertations from 1937

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The effect of splenectomy on the differential cell count of the anterior pituitary in relation to post-splenectomy changes in the blood picture of the dog., Herbert J. Brinker