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Health and Sport Sciences


Background—Metabolic syndrome (MetS) has been linked with an increased risk of developing cancer; however the association between MetS and cancer mortality remains less clear. Little research has focused on pre-cancer risk factors that may affect the outcome of treatment. The purpose of this study was to examine the association between MetS and all-cancer mortality in men. Methods—The participants included 33,230 men aged 20-88 years who were enrolled in the Aerobics Center Longitudinal Study and free of known cancer at baseline. Results—At baseline 28% of all the participants had MetS. During an average of 14 years followup there were a total of 685 deaths due to cancer. MetS at baseline was associated with a 56% greater age-adjusted risk in cancer mortality. Conclusion—These data show that MetS is associated with an increased risk of all-cause cancer mortality in men. Based on these findings it is evident that successful interventions should be identified to attenuate the negative effects of MetS.


This is a NIH-PA Author Manuscript. The article is published in final, edited form as: Eur J Cancer. 2009 July ; 45(10): 1831–1838. doi:10.1016/j.ejca.2009.01.031

Original Publication Information

Jaggers, Jason R., Xuemei Sui, Steven P. Hooker, Michael J. LaMonte, Charles E. Matthews, Gregory A. Hand, Steven N. Blair. "Metabolic syndrome and risk of cancer mortality in men." 2009. European Journal of Cancer 45(10): 1831-1838.