Date on Senior Honors Thesis


Document Type

Senior Honors Thesis



Degree Program

College of Arts and Sciences

Author's Keywords

Flagella; Burkholderia dolosa, Toll-like receptor 5; TLRS; Human immune response


Cystic Fibrosis (CF) is the most commonly inherited lethal disorder in Caucasian populations. Chronic bacterial infection both decreases lung function and lowers the quality of the CF patient’s life. In one of the most recent CF epidemics, Burkholderia dolosa, an organism previously uncharacterized as an epidemic strain, infected over forty patients and led to the death of over seven patients at Children’s Hospital Boston. Preliminary research revealed that this strain of B. dolosa possesses genes for two distinct types of flagella, which is uncommon in bacterial pathogens. In this study we examine the interaction of human cells and B. dolosa, focusing on the human inflammatory response to these two types of B. dolosa flagella. The findings of this study could provide insight into B. dolosa pathogenesis, so that effective therapeutics may be designed to combat this organism in the future.

Included in

Biology Commons