Introduction: Experts suggest a short duration of antibiotic therapy (DOT) in responding patients with community-acquired pneumonia (CAP). The aim of this study was to evaluate clinical outcomes after hospital discharge among patients treated with short-course antibiotic therapy (SCT) vs. long-course antibiotic therapy (LCT) for CAP.
Methods: A secondary analysis of the Community-Acquired Pneumonia Organization (CAPO) database from January 2007 to June 2013 was performed, including hospitalized CAP patients who reached clinical stability within 5 days. Two groups were identified: patients who were treated with antibiotic therapy for a total duration of 5 days or less (SCT Group) vs. longer than 5 days (LCT Group). Rehospitalization and mortality were evaluated at 30 days after discharge.
Results: 1,849 patients were enrolled (58% males; median age: 65 years), 179 (10%) were included in the SCT and 1,670 (90%) in the LTC group. Median DOT was 5 days in the SCT and 10 days in the LTC group, p
Conclusions: A duration of antibiotic therapy of ≤ 5 days does not adversely impact clinical outcomes at 30-days after discharge compared to >5 days in patients who reached early clinical stability.
Chirino Navarta, Alejandro; Peyrani, Paula; Wiemken, Timothy L.; Restrepo, Marcos I.; Chalmers, James D.; Luna, Carlos M.; Blasi, Francesco; Ramirez, Julio A.; and Aliberti, Stefano
"Short Duration of Antibiotic Therapy in Hospitalized Patients with Community-Acquired Pneumonia: Results from the CAPO International Cohort Study,"
The University of Louisville Journal of Respiratory Infections: Vol. 1
, Article 6.
Available at: https://ir.library.louisville.edu/jri/vol1/iss3/6
Community Health and Preventive Medicine Commons, Epidemiology Commons, Health Information Technology Commons, Influenza Humans Commons, Influenza Virus Vaccines Commons, International Public Health Commons, Translational Medical Research Commons