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The University of Louisville Journal of Respiratory Infections

Abstract

Introduction

Community-acquired pneumonia (CAP) is a leading cause of death worldwide. Chronic obstructive pulmonary disease (COPD) is a well-established risk factor for development of CAP. What is not as clear is the impact of COPD in the outcomes of patients with CAP. In this study, we compared the outcomes of CAP in COPD and non-COPD patients.

Methods

This was a retrospective cohort study. We conducted a secondary analysis of the Community-Acquired Pneumonia Organization (CAPO) international cohort study database, which includes patients with CAP admitted to several hospitals throughout the world. Outcomes were time to clinical stability, length of hospital stay, and in-hospital mortality.

Results

This study included 7,325 patients. Of these, 1,869 (25.5%) had COPD. Patients with COPD had higher severity of illness (pneumonia severity index class V: 15% vs 9%; P

Conclusion

Our study results show that COPD should not be considered a risk factor for poor outcomes in hospitalized patients with CAP.

DOI

10.18297/jri/vol1/iss3/8/

jri011-Table_1.png (238 kB)
Table 1: Characteristics of the patients.

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Fig. 1: Kaplan-Meier curves and log-rank test comparing probability of hospital discharge between COPD and non-COPD patients.

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Fig. 2: Kaplan-Meier curves and log-rank test comparing time to clinical stability between COPD and non-COPD patients.

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Table 2: Multiple logistic regression assessing the effect of variables on in-patient mortality.

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Fig. 3: Accelerated failure time model comparing adjusted probability of discharge between COPD and non-COPD patients (dotted lines represent 95% confidence interval).

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Fig. 4: Accelerated failure time model comparing adjusted probability of clinical stability between COPD and non-COPD patients (dotted lines represent 95% confidence interval).

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jri011-Fig_3-thumbnail.png (36 kB)
jri011-Fig_4-thumbnail.png (33 kB)

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