•  
  •  
 
The University of Louisville Journal of Respiratory Infections

IRB 11.0613

Abstract

Background: Liver disease and cirrhosis are common causes of mortality worldwide. Community-acquired pneumonia is recognized as a significant cause of morbidity and mortality in this population. There is lack of data showing outcomes or prognosis in patients with liver dysfunction who develop CAP. The objective of this study was to evaluate the clinical characteristics, incidence, and outcomes of hospitalized patients with CAP and liver disease.

Methods: This was a secondary analysis of the University of Louisville Pneumonia Study which was a prospective population-based cohort study of adults with community-acquired pneumonia. All patients were divided into three groups: 1)patients without liver disease, 2) patients with liver disease, and 3) patients with cirrhosis. Short and long-term outcomes were analyzed.

Results: Compared to patients without liver disease, we found no significant difference in time to clinical stability for patients with liver diseases (aHR: 1.01, 95% CI: 0.92 – 1.12; p=0.790), or cirrhosis (aHR: 0.85, 95% CI: 0.69 – 1.05; p=0.127). There were also no differences in median length of stay (LOS) between any two groups. Patients with cirrhosis had 35% higher risk of death at any time compared to patients with no liver disease (aHR: 1.35, 95% CI: 1.00-1.82; p=0.049), but did not have significantly increased risk compared to patients with liver disease (aHR: 1.37, 95% CI: 0.97 – 1.93, p=0.070).

Conclusions: In this study of hospitalized with CAP, patients with cirrhosis had significantly higher risk of death compared to patients without liver disease.

Funder

The author(s) received no specific funding for this work

DOI

10.18297/jri/vol4/iss2/3

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Figure 1. Flow chart for three groups of study population are shown..pdf (170 kB)
Flow chart for three groups of study population are shown.

Figure 2. Kaplan-Meier curves for time to clinical stability for study population are shown.pdf (4 kB)
Kaplan-Meier curves for time to clinical stability for study population are shown

Figure 3. Kaplan Meier curve for Length of stay for study population are shown..pdf (4 kB)
Kaplan Meier curve for Length of stay for study population are shown.

Figure 4. Survival curve for study population are shown..pdf (8 kB)
Survival curve for study population are shown.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.