Document Type
Article
Publication Date
Fall 10-4-2017
Department
Medicine
Department
Pharmacology and Toxicology
Department
Epidemiology and Population Health
Abstract
Background
Controversy still exists regarding gender differences in virologic response between treatment-na•ve HIV-infected individuals. The objective of this study was to evaluate gender difference in virologic and immunologic response to antiretroviral therapy in treatment-na•ve HIV-infected individuals. Methods
This was a retrospective, observational study of treatment-na•ve HIV-infected individuals managed at the 550 clinic who started antiretroviral therapy (ART) between January 1st, 2010 and December 31, 2015. Patients with available viral load and CD4 counts before and one year after initiating ART were included in this study. Virologic suppression was defined as < 48 HIV-1 RNA copies/mL, and mmunologic recovery was defined as a CD4 count increase of at least 150 cells/mm3. Dichotomous variables were reported in number and percentages and analyzed using Chi-squared tests and Fisher’s exact (whichever was appropriate). Continuous variables were reported as median and interquartile range (IQR) and analyzed using Wilcox rank-sum tests. Multivariate analyses performed were logistic regressions with adjustment for other covariates. P value <0.05 was considered statistically significant. R version 3.3.2 was used for the statistical analysis. Results
A total of 70 women and 90 men were included in the study. Median age was 41 years (19) for women and 34 years (19) for men (P < 0.001). Virologic suppression was documented in 76% of women and 64% of men (p 0.166). Immune recovery was documented in 60% of women and 68% of men (p 0.323). Multivariate analysis of virologic success is shown in Figure 1 and immunologic recovery is shown in Figure 2. Open in new tabDownload slide Open in new tabDownload slide Conclusion
In our study, gender was not found to be associated with differences in response to ART. As expected, drug abuse continues to be an independent variable associated with lack of virologic suppression. If one of the goals of treatment is to achieve a rapid immunologic response, our study may indicate that regimens containing protease inhibitors should be the ones selected.
Original Publication Information
Open Forum Infectious Diseases, Volume 4, Issue suppl_1, Fall 2017, Pages S432–S433, https://doi.org/10.1093/ofid/ofx163.1093 Published: 04 October 2017
Session: 156. HIV: Antiretroviral Therapy
Friday, October 6, 2017: 12:30 PM
© The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comThinkIR Citation
Reyes-Vega, Andrea; Loban, Alejandra; Srinivasan, Kavitha; Furmanek, Stephen P.; English, Conner; Bishop, Mary; Spencer, Cathy; Truelove, Daniel; Ramirez, Julio A.; Raghuram, Anupama; and Peyrani, Paula, "Gender differences in virologic response after antiretroviral therapy in treatment-naïve HIV-infected individuals: Results from the 550 clinic HIV cohort study." (2017). Faculty Scholarship. 953.
https://ir.library.louisville.edu/faculty/953
DOI
doi.org/10.1093/ofid/ofx163.1093
ORCID
0000-0003-1633-6097
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