Date on Master's Thesis/Doctoral Dissertation


Document Type

Master's Thesis

Degree Name



Pharmacology and Toxicology

Committee Chair

Eaton, John Wallace, 1941-


Antioxidants--Therapeutic use; Atherosclerosis--Prevention


The leading cause of death in the United States is cardiovascular disease, a result of atherosclerosis. The reducing agent N-(2-Mercaptopropionyl)glycine (MPG) as been found to be an effective antioxidant therapy in a number of conditions, and our hypothesis is that it will be an effective agent in the detoxification of oxidized lipids in atherosclerosis. Our results indicate some protective effect, along with some toxicity at high doses, with refinement of the experimental model necessary before results can be conclusive. Nevertheless, antioxidant and aldehyde-quenching agents in general have been shown to be of benefit in the detoxification of oxidized lipids, and MPG is still therefore a good candidate. Since this is yet another mechanism used to combat the disease, we hypothesize that such reducing agents will complement other therapies quite effectively, providing an even more effective means of preventing the onset, as well as reversing the progression of atherosclerosis.