Date on Master's Thesis/Doctoral Dissertation


Document Type

Master's Thesis

Degree Name



Oral Biology

Committee Chair

Chandiramani, Sunita S.


Fluorides--Therapeutic use; Orthodontic appliances; Dental bonding


Introduction: Although orthodontics can correct a variety of dental and skeletal malocclusions, research has shown an increased risk of enamel demineralization leading to white spot lesions (WSLs). The purpose of this study was to compare the effectiveness of Pro Seal and Opal Seal, two fluoridated bonding agents, to Assure, a nonfluoridated bonding agent, in preventing demineralization during orthodontic treatment. Methods: 26 patients beginning comprehensive orthodontic treatment were divided into 3 groups. 9 patients were bonded with Assure (control), 9 patients were bonded with Pro Seal, and 8 patients were bonded with Opal Seal. Pretreatment and six-month progress photographs were used to calculate demineralization rates, and statistical analysis was performed to determine if any bonding agent is better at preventing WSLs. Results: There was no statistically significant difference in demineralization rates between the three bonding agents; however, descriptive statistics suggest that Pro Seal and Opal Seal may prevent demineralization more effectively than Assure.