Date on Master's Thesis/Doctoral Dissertation
University of Louisville
JB Speed School of Engineering
Committee Co-Chair (if applicable)
Cancer; tumor-associated macrophages; TIE-2 macrophages; mathematical modeling; computational simulation
The most abundant immune cell types of the tumor microenvironment macrophages recruited there by tumor-eluted factors. The role of these immune cells in tumor progression, and the interplay between tumor and immune cells is an emerging field of research with potential for novel treatment strategies. Here, a TIE2 expressing macrophage (TEM) subtype is integrated into a virtual tumor model. Within the 2D microenvironment, the TEM will differentiate from an extravasated monocyte precursor, congregate around the abluminal side of the vasculature in response to a chemoattractant gradient, secrete cytokines which favor differentiation of a separate angiogenic macrophage subtype . The effects of macrophage populations on tumor progression on angiogenic activity and tumor growth will be examined.
Mahlbacher, Grace E., "Examining the effects of macrophage populations on cancerous tumor growth." (2017). Electronic Theses and Dissertations. Paper 2816.