Date on Master's Thesis/Doctoral Dissertation
Anatomical Sciences and Neurobiology
Anatomical Sciences and Neurobiology, MS
Van Wouwe, Nelleke
DBS; Parkinson's disease; neurologyn; neurological surgery; verbal fluency
This study investigated the cortical-striatal networks of verbal fluency declines in 6-month, post-operative, deep brain stimulation Parkinson’s Disease patients. Nine Parkinson’s disease participants with implanted STN or GPi DBS systems were recruited for this study. Verbal fluency data was obtained from each patient preoperatively and 6- months post implantation. The stimulation-based volume of tissue activated area (VTA) of each target site (STN or GPi) was analyzed using Lead-DBS and Lead-Group. The white matter tracks intersecting each patient’s VTA, terminating in the pre-SMA, SMA, caudate nucleus, and anterior cingulate were investigated and correlated with verbal fluency declines. We found statistically significant effects of DBS on verbal fluency, with a trendtowards greater declines in the STN compared to the GPi. Verbal fluency declines were found to be the greatest in patients with more white matter tracts leading from the left hemisphere to the left caudate and bilaterally to the pre-SMA and SMA, and there were no correlations found between VF and the anterior cingulate.
Alley, Alexander Luke, "The impact of volume of tissue activation on cortical-striatal networks and verbal fluency declines in post-deep brain stimulation Parkinson's disease patients." (2022). Electronic Theses and Dissertations. Paper 3879.
Retrieved from https://ir.library.louisville.edu/etd/3879