Date on Master's Thesis/Doctoral Dissertation

5-2022

Document Type

Master's Thesis

Degree Name

M.S.

Department

Anatomical Sciences and Neurobiology

Degree Program

Anatomical Sciences and Neurobiology, MS

Committee Chair

Neimat, Jospeh

Committee Co-Chair (if applicable)

Van Wouwe, Nelleke

Committee Member

Van Wouwe, Nelleke

Committee Member

Underwood, Robert

Author's Keywords

DBS; Parkinson's disease; neurologyn; neurological surgery; verbal fluency

Abstract

This study investigated the cortical-striatal networks of verbal fluency declines in 6-month, post-operative, deep brain stimulation Parkinson’s Disease patients. Nine Parkinson’s disease participants with implanted STN or GPi DBS systems were recruited for this study. Verbal fluency data was obtained from each patient preoperatively and 6- months post implantation. The stimulation-based volume of tissue activated area (VTA) of each target site (STN or GPi) was analyzed using Lead-DBS and Lead-Group. The white matter tracks intersecting each patient’s VTA, terminating in the pre-SMA, SMA, caudate nucleus, and anterior cingulate were investigated and correlated with verbal fluency declines. We found statistically significant effects of DBS on verbal fluency, with a trendtowards greater declines in the STN compared to the GPi. Verbal fluency declines were found to be the greatest in patients with more white matter tracts leading from the left hemisphere to the left caudate and bilaterally to the pre-SMA and SMA, and there were no correlations found between VF and the anterior cingulate.

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