Date on Master's Thesis/Doctoral Dissertation
Pharmacology and Toxicology
Pharmacology and Toxicology, MS
Cardiovascular disease; atherosclerosis; endothelium; VOCs; exposure
Pollution has been identified as the leading environmental cause of non-communicable disease and premature deaths globally. Volatile organic compounds (VOCs) are gaseous chemical constituents of pollution derived from a variety of sources, including industrial solvents and byproducts, automobile exhaust, tobacco smoke, cleaning supplies, and personal care products. VOCs are also abundant at various Superfund and Hazardous Waste Sites. Emerging data suggest that VOC exposure is associated with several adverse health outcomes, including cardiovascular disease (CVD). VOCs and their metabolites can potentially damage the endothelial lining of blood vessels, resulting in perturbed vascular function and vascular inflammation. We hypothesize that VOC exposure augments CVD risk, which is reflected by significant changes in subclinical biomarkers. To examine the effects of VOC exposures on vascular inflammation, we measured associations between urinary metabolites of VOCs and biomarkers of CVD, including microparticles and circulating angiogenic cells.
Taylor, Breandon Scot, "The impact of volatile organic compound exposure on subclinical biomarkers of cardiovascular injury." (2022). Electronic Theses and Dissertations. Paper 4004.
Retrieved from https://ir.library.louisville.edu/etd/4004