Date on Master's Thesis/Doctoral Dissertation


Document Type

Master's Thesis

Degree Name



Pharmacology and Toxicology

Degree Program

Pharmacology and Toxicology, MS

Committee Chair

Ceresa, Brian

Committee Co-Chair (if applicable)

Siskind, Leah

Committee Member

Siskind, Leah

Committee Member

Clark, Geoffrey

Committee Member

Petruska, Jeffrey

Committee Member

Scott, Patrick

Author's Keywords

c-Met; HGF; cornea; wound healing; Cbl


Vision is often regarded as the primary sense of humans. The cornea is the main refractive tissue that permits light through to the retina, allowing a clear image. When the cornea sustains damage, it opens a pathway for infection and blindness through fibrotic processes. Healing the corneal tissue is critical for vision restoration and pain alleviation. Growth factors and their cognate receptors are currently under investigation as tools to restore proper corneal physiology. We hypothesize that manipulating the hepatocyte growth factor (HGF)/ c-Met signaling pathway is one route to promote quality corneal healing. This thesis investigates the signaling, trafficking, and degradation pathway of c-Met following HGF stimulation in corneal epithelial cells. Results indicate that regulating the Cbl proteins, E3 ligases that tag c-Met for degradation, can extend receptor signaling and accelerate re-epithelialization.