Date on Master's Thesis/Doctoral Dissertation
Chlamydia trachomatis; SARS-CoV-2; Plasmodium, virulence, evolution, transmission
Principles of natural selection have proven valuable for explaining why pathogens cause the diseases that they do. In theory, the evolved level of host exploitation should reflect how dependent a pathogen is on host health for transmission. This dependency is shaped by transmission mode and transmission opportunity, which should therefore be predictors of disease manifestations. In this dissertation, I apply these principles to investigations of depression in Chlamydia trachomatis and virulence of SARS-COV-2 and Plasmodium species. This dissertation has five chapters. In chapter I, I describe the theoretical foundation of my dissertation research. I also briefly introduce each study system. In chapter II, I evaluate whether C. trachomatis is associated with depression based on a candidate mechanism for within-host persistence. I hypothesize that C. trachomatis should be associated with depression independent of urogenital symptoms, and that the effect should be stronger in females than in males. In chapter III, I assess evolutionary trends in SARS-CoV-2’s virulence and viral loads by conducting meta-analyses of published results. From the evolutionary perspective that virulence of respiratory pathogens should correlate positively with environmental survivability, I hypothesize a trend of reduced virulence. In chapter IV, I qualitatively review epidemiological factors that may affect malaria severity and critically evaluate the hypothesis that virulence evolves as a function of transmission intensity. In chapter IV, I summarize the main findings and conclusions from chapters II through IV. I also discuss future research directions and potential applications.
Steffens, Nathan, "Transmission and the evolution of diseases caused by chlamydia trachomatis, SARS-CoV-2, and plasmodium species." (2023). Electronic Theses and Dissertations. Paper 4116.
Retrieved from https://ir.library.louisville.edu/etd/4116