Date on Master's Thesis/Doctoral Dissertation
Pharmacology and Toxicology
Pharmacology and Toxicology, MS
Moore IV, Joseph
particulate matter 2.5; telomeres; aging; epigenetics; cellular senescence; environmental exposure; air pollution
In recent years, research into air pollution has shown that exposure to certain components in air pollution, primarily PM2.5 can accelerate biological aging and thereby lead to increased susceptibility to multiple diseases. We hypothesize that prolonged exposure to air pollutants can result in premature aging leading to extensive tissue dysfunction and susceptibility to diseases. To examine this, we exposed mice to PM2.5 for 9, 15, and 21 days, then measured the telomere lengths, cellular senescence, and histone methylation patterns of multiple cell types. We found consistently increased telomere attrition, cellular senescence and advanced age-consistent histone methylation patterns in groups exposed to PM2.5 across all examined cell types. Our investigation provides ample evidence that exposure to PM2.5 can cause premature aging and has the potential to lead to diseases such as cardiovascular disorders, type II diabetes, immune system dysfunction, and neurodegenerative disorders.
Gomes, Daniel Chris, "Environmental exposures and aging." (2023). Electronic Theses and Dissertations. Paper 4192.
Retrieved from https://ir.library.louisville.edu/etd/4192