Treatment of severe aortic stenosis : experimental design, testing, and analysis of an aortic valve bypass apical cannula.
Date on Master's Thesis/Doctoral Dissertation
Koenig, Steven Christopher
Aortic valve bypass; Aortic stenosis; Cannula
Heart valve prosthesis; Coronary artery bypass
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from the apex of the left ventricle to the descending thoracic aorta. Blood is ejected from the left ventricle via both the native stenotic aortic valve and the conduit. This thesis proposes a design for one of the least developed components of this system, the cannula component that sits inside the left ventricle and allows for flow of blood from the left ventricle and into the conduit. Experimental use of mock flow loop testing and computational flow dynamics analysis (ANSYS Inc., Canonsburg, PA, U.S.A.) on prototype and currently used clinical venous cannulas were used in the development and design of the proposed apical cannula. Aortic valve bypass results in a low gradient across the native stenotic valve and a small gradient across the conduit. The results from the mock loop experiments, CFD analysis, clinical data, and findings from previous researchers have aided in design of a new apical cannula. It is hoped that this cannula will be a more favorable design over currently used apical connectors. Further in vitro and in vivo studies are needed to validate these results.
Graham, Joel Douglas, "Treatment of severe aortic stenosis : experimental design, testing, and analysis of an aortic valve bypass apical cannula." (2010). Electronic Theses and Dissertations. Paper 523.