Analysis of the Local and Systemic Cytokine Response Profiles in Patients with Community-Acquired Pneumonia. Relationship with Disease Severity and Outcomes.

Authors

Rafael Fernandez-Botran, University of LouisvilleFollow
Timothy Lee Wiemken, University of LouisvilleFollow
Robert R. Kelley, University of LouisvilleFollow
Paula Peyrani, University of LouisvilleFollow
Jose Bordon, Providence HospitalFollow
Rodrigo Cavallazzi, University of LouisvilleFollow
Julio A. Ramirez, University of LouisvilleFollow

Funder

The author(s) received no specific funding for this work.

Abstract

The goals of this study were to investigate the relationship of systemic and local cytokine responses with time to clinical stability (TCS) in patients with community-acquired pneumonia (CAP) and to develop a model to integrate multiple cytokine data into “cytokine response profiles” based on local vs. systemic and pro- vs. anti-inflammatory cytokine patterns in order to better understand their relationships with measures of CAP severity and outcomes. Forty hospitalized patients enrolled through the Community Acquired Pneumonia Inflammatory Study Group (CAPISG) were analyzed. Based on the ranked distribution of the levels of eight different pro-inflammatory cytokines and chemokines (IL-1b, IL-6, IL-8, IL-12p40, IL-17A, IFNg, TNFa and CXCL10) in plasma and sputum on hospital admission, a “pro-inflammatory cytokine score (PICS)” was defined. PICS in plasma and sputum were plotted against each other and quadrants used to define profiles based on the four possible high/low combinations. A similar approach was used to contrast sputum PICS vs. anti-inflammatory cytokines (IL-1ra and IL-10). Some of the “profiles” thus defined were found to group patients with common etiologic characteristics and/or associate with similar measures of disease severity and/or clinical outcomes, suggesting the predictive value of the use of cytokine data in CAP patients.

DOI

10.18297/jri/vol1/iss3/5/

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Fernandez-Botran, Rafael; Wiemken, Timothy Lee; Kelley, Robert R.; Peyrani, Paula; Bordon, Jose; Cavallazzi, Rodrigo; and Ramirez, Julio A. (2017) "Analysis of the Local and Systemic Cytokine Response Profiles in Patients with Community-Acquired Pneumonia. Relationship with Disease Severity and Outcomes.," The University of Louisville Journal of Respiratory Infections: Vol. 1 : Iss. 3 , Article 5.
DOI: https://doi.org/10.18297/jri/vol1/iss3/5/
Available at: https://ir.library.louisville.edu/jri/vol1/iss3/5