Aspergillosis is acquired by inhalation of spores of Aspergillus, a ubiquitous species in the environment. In normal hosts, spore inhalation rarely causes lung disease.
Pulmonary aspergillosis covers a wide spectrum of clinical syndromes depending on the interaction between Aspergillus and the host (immune-status, prior bronchopulmonary disease). It runs the gamut from invasive aspergillosis to Aspergillus bronchitis and colonization.
Invasive aspergillosis occurs in severely immunocompromised patients, typically with neutropenia. Chronic pulmonary aspergillosis affects patients with chronic structural lung disease such as chronic obstructive pulmonary disease, mycobacterial lung disease, but without significant immunocompromise. Aspergillus bronchitis affects patients with bronchial disease such as bronchiectasis. Allergic bronchopulmonary aspergillosis affects patients with bronchial asthma or cystic fibrosis, and is due to an allergic response to Aspergillus.
In this review of literature, we discuss the pulmonary manifestations of Aspergillus infection, its diagnosis and treatments.
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Jalil, Bilal A.; Galvis, Juan M.; El Kersh, Karim A.; Saad, Mohamed; Fraig, Mostafa M.; and Guardiola, Juan J. II
"Pulmonary Aspergillosis: A Review on Diagnosis and Management,"
The University of Louisville Journal of Respiratory Infections: Vol. 2
, Article 6.
Available at: https://ir.library.louisville.edu/jri/vol2/iss2/6
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