It has become increasingly evident that a high percentage of patients that recover from acute COVID-19 infection continue to suffer from a variety of persistent symptoms even months after viral clearance, the most common ones being fatigue, dyspnea, anosmia, dysgeusia, cognitive dysfunction, and psychological problems, including anxiety and depression. This syndrome, known as Post-acute sequelae of COVID-19 (PASC), can severely affect the life quality and represents an important health care concern. The exact causes for the symptoms observed in patients with PASC remain to be adequately characterized, but are likely to be associated with multiple factors, including residual disease and/or inflammation, organ damage, effects of hospitalization and/or prolonged ventilation, as well as effects of social isolation and stress. This mini-review discusses evidence that may link both inflammatory and auto-immune processes in the pathophysiology of PASC.
The authors received no specific funding for this work
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Ambadapoodi, Raghava S.; Deepti, Fnu; Anwer, Javaria MBBS; and Fernandez-Botran, Rafael
"Post-Acute Sequelae of COVID-19 (PASC): Association with Inflammation and Autoimmunity,"
The University of Louisville Journal of Respiratory Infections: Vol. 5
, Article 20.
Available at: https://ir.library.louisville.edu/jri/vol5/iss1/20