This collection includes theses and dissertations from the Department of Microbiology and Immunology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2022

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Aggregatibacter actinomycetemcomitans exploits and modulates the immune response by human neutrophils for survival in the anaerobic environment., Hazel Ozuna

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Induction of trained immunity by particulate β-glucan controls cancer metastasis through the sphingolipids-mediated mitochondrial fission pathway., Rejeena Shrestha

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Lysosomal evasion of legionella pneumophilia the effector., Bethany Vaughn

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Defining the importance of the hnRNP I interaction to the Sindbis virus subgenomic viral RNA using an innovative tethering approach., Claire Westcott

Theses/Dissertations from 2021

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Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control., Anne Elena Geller

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Sex-based differences in microbiota composition and metabolomic profiles associated with altered macrophage function and protection from lupus in BWF1 mice., James William Harder

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The importance of noncapped viral genomic RNA to alphaviral infection and pathogenesis., Autumn LaPointe

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Q-Griffithsin interactions and utility for the prevention and treatment of Mucosal infections., Henry Nabeta

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Determination of the biological functions of undefined domains of VEEV nsP2., Andrew Michael Skidmore

Theses/Dissertations from 2020

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Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules., Christopher Lynn Harding

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Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis., Dylan MacGregor Johnson

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The emerging oral pathogen, filifactor alocis, disrupts neutrophil functions to enhance survival and dysregulate inflammation., Irina Miralda Molina

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Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through NF-Kβ dependent glycolytic metabolic reprogramming., Samantha M. Morrissey

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Modulation of host innate immune cells by Yersinia pestis to create a permissive environment for replication., Amanda Rose Pulsifer

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Identification and structural characterization functional motifs in the Porphyromonas gingivalis MFA1 short fimbria., Mohammad K. Roky

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Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses., Pradeep Shrestha

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Tissue-resident myeloid-derived suppressor cells modulate immune homeostasis in healthy adipose., Katlin Brooke Stivers

Theses/Dissertations from 2019

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A distinct pattern of sterile inflammation induced by zinc oxide nanowires., Ruqaih Salem Alghsham

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The manipulation of host transcription by the ANKH effector of legionella., Juanita E. Von Dwingelo

Theses/Dissertations from 2018

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Nutritional virulence of Legionella pneumophila., Ashley M. Best

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Combination oral immunotherapy with IL-10 and IL-12 effectively treats colon tumors via synergistic effects on IL-17 producing T cells and colon epithelial barrier integrity., Neal Bhutiani

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CD11b regulation of B cell receptor signaling in health and systemic lupus erythematosus., Paul Lorenzo Dascani

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Characterizing the gut microbiota during plasmodium infection and antimalarial treatment., Joshua E. Denny

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Inflammasome independent leukotriene-b4 production drives crystalline silica induced sterile inflammation., Bindu Hegde

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Divergent evolution of di-lysine ER retention vs. farnesylation motif-mediated anchoring of the ankb virulence effector., John David Perpich

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Characterization of type II toxin anti-toxin systems in Aggregatibacter actinomycetemcomitans., Blair W. Schneider

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Characterizing the virulence factor YapE in Yersinia pestis., Tiva Templeton VanCleave

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The involvement of epithelial cells in arenavirus-induced pathogenesis., Nikole Leslie Margaret Warner

Theses/Dissertations from 2017

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Characterization of Filifactor alocis and its immune evasion strategies employed against human neutrophils., Cortney Linn Armstrong

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The DLK1-MEG3 locus in malignant cells of proposed primordial germ cell origins., Zachariah Payne Sellers

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Revisiting neutrophil responses to toll-like receptor 4 : influence of ligand structures and cellular environments., Shuvasree Sengupta

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Targeting Fas pathway as an effective means of inducing tolerance to pancreatic islets., Kyle Blake Woodward

Theses/Dissertations from 2016

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Immune monitoring in recipients of combined living donor kidney and hematopoietic stem/facilitating cell transplants., Mark DeWayne Badder

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SA-4-1BBL as a modulator of innate, adaptive, and regulatory immunity : implications for cancer prevention and treatment., Hampartsoum Barsoumian

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Identification of host factors required for Yersinia pestis macrophage intracellular survival and their impact on vacuole maturation, acidification and trafficking., Michael Graylin Connor

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Impact of epigallocatechin-3-gallate (EGCG), a broad-spectrum anti-inflammatory, in controlling intestinal factors contributing to inflammatory bowel disease., Gerald Wayne Dryden, Jr.

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Microbiota activated CD103+ DCS stemming from oral microbiota adaptation specifically drive γδT17 proliferation and activation., Christopher Jay Fleming

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In vivo monitoring of therapeutic efficacy and virulence profile by bioluminescent Klebsiella pneumoniae., Ramy Ameen Fodah

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Characterization of the role of the Burkholderia pseudomallei type 3 secretion system using in vivo imaging., Maria Gabriela Gutierrez

Theses/Dissertations from 2015

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Immunomodulation of myeloid-derived suppressor cells by particulate b-glucan in cancer., Sabrin Husein Albeituni

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Critical insights into the pathogenesis of clinical isolates of pandemic influenza A(H1N1) 2009 virus in mouse and ferret models., Jeremy V. Camp 1980-

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Chemoattractant receptors BLT1 and CXCR3 regulate anti-tumor immunity by facilitating CD8+ T cell migration to tumors., Zinal S. Chheda

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Early host response and immune signaling to 2009 pandemic influenza A (H1N1) viruses in primary cell culture models., Rachael Lask Gerlach

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Characterization of the innate response to the RagB protein of Porphyromonas gingivalis., Justin Hutcherson

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Functional characterization of Aggregatibacter actinomycetemcomitans QSEBC : a bacterial adrengeric receptor and global regulator of virulence., Whitney Weigel

Theses/Dissertations from 2014

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Modulation of host polyubiquitination by the ankb f-box protein of Legionella pneumophila., William M. Bruckert

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SA-4-1BBL as a platform to develop adjuvant systems for prophylactic and therapeutic vaccines., Gunes Dinc 1984-

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A mechanism for trif adaptor-biased signaling by toll-like receptor 4., Joseph Peterson Kolb

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IL-12 induced modulation of tumor derived myeloid cell inflammatory responsiveness., Courtney Jetun Mitchell

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Modulation of the ovarian cancer humoral response by tumor-derived exosomes., Carolyn Denise Roberson

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Regulation of macrophage inflammatory signaling pathways by AMP-activated protein kinase., Yanfang Zhu

Theses/Dissertations from 2013

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Mast cell-T cell interactions in inflammatory chemokine mediated immune surveillance of intestinal cancer., Sobha R. Bodduluri

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AMP-activated protein kinase regulation of myeloid antigen presenting cell activity., Kelly Casey Carroll

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The involvement of beta-catenin in the inflammatory response leading to autoimmune diabetes development., Arin Lee Zirnheld

Theses/Dissertations from 2012

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Blockade of CXCR4 inhibits Porphyromonas gingivalis colonization in vivo and subsequent periodontal bone loss., Megan L. Mc Intosh

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Expression of adipocyte/macrophage fatty acid binding protein promotes tumor growth and metastasis., Ashley Simone Triplett

Theses/Dissertations from 2011

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Identification and biochemical characterization of the CHLAMYDIA TRACHOMATIS type III secretion chaperone, SLC1, and its role in the translocation of the invasion-associated effector TARP., Amanda J. Brinkworth

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Reconciliation of IL-1ß loss with TRIF-biased TLR4 signaling by monophosphate lipid A., Chelsea A. Embry

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Age-associated changes in innate immunity and their impacts on inflammatory disease., Mehmet Akif Eskan

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Effect of complement C5a in tumor progression and the local tumor microenvironment., Lacey Jo Gunn

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Characterization of the AI-2-dependent quorum sensing pathway in Aggregatibacter actinomycetemcomitans., Elizabeth A. Novak

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Exploitation of costimulatory SA-4-1BBL in the development of therapeutic cancer vaccines., Abhishek K. Srivastava

Theses/Dissertations from 2010

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Tobacco-induced changes to Porphyromonas gingivalis gene expression, phenotype and host-pathogen interactions., Juhi Bagaitkar

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'Complementary' immune evasion by oral pathogen Porphyromonas gingivalis., Jennifer Lynn Krauss

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SA-4-1BBL as a modulator of T effector to T regulatory cell conversion., Shravan Madireddi 1980-

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A role for regulatory T cells in gender-biased disease susceptibility to murine lupus., Colleen Tucker

Theses/Dissertations from 2009

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The role of glycogen synthase kinase 3-beta in interferon beta biology., Huizhi Wang 1975-

Theses/Dissertations from 2007

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Non-redundant and critical roles for leukotriene B4 receptors BLT1 and BLT2 in mouse models of inflammatory arthritis., Steven Mathis 1979-

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Therapeutic targeting of tumor associated macrophages., Stephanie Kaye Watkins 1981-

Theses/Dissertations from 2006

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Molecular pathogenesis of Legionella longbeachae., Rexford Asare 1972-

Theses/Dissertations from 2005

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Sex-based differences in regulatory T cells., Lum Doreen Nebane-Ambe 1975-

Theses/Dissertations from 2002

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Structure-function studies of the vaccinia virus complement control protein., Scott Alan Smith

Theses/Dissertations from 2001

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Characterization of secA-sod operon in Borrellia burgdorferi., Tonya Lynn Nichols

Theses/Dissertations from 1932

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The cause of vascular sclerosis in essential hypertension and related phenomena, Claude W. Chappell