This collection includes theses and dissertations from the Department of Bioengineering, in the J.B. Speed School of Engineering. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 (Master of Engineering, prior to 2005) can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2022

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Release kinetics of metronidazole from 3D printed silicone scaffolds., Sydney E. Herold

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Fabrication and characterization of Lactobacillus Crispatus containing bioprints for bacterial vaginosis application., Anthony J. Kyser

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Machine learning analysis of acoustic attenuation measurements for cellular characterization., John T. Moore

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Acoustofluidic delivery of gene editing compounds for improved immunotherapy processing., Riyakumari K. Patel

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Effect of dorsal quadrant or ventral quadrant spinal cord injury on gait features during locomotion., Anya Nicole Trell

Theses/Dissertations from 2021

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COVID-19 Serological Diagnostic Development Using A SARS-CoV-2 RBD Foldon Fusion, Joey Emery Breckenridge Jr.

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Automated conversion of MultiCellDS Digital Cell Lines and ISA-Tab filesets., Connor Joseph Burns

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Conversion of MultiCellDS Digital Snapshots to ISA-Tab format., Corey P. Chitwood

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Biomechanical Characterization of Video-Recorded Short-Distance Falls Involving Children Equipped with a Biometric Device in a Childcare Setting: A Pilot Study., Danielle K. Cory

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Refinement and automation using algorithmic control of BreathForce, a respiratory training system for patients with spinal cord Injuries., Anna Goestenkors

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Update of MultiCellular data standard to match PhysiCell "compact" output., Reid A Honeycutt

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CFD analysis of acoustofluidic channels and the effects on biologic delivery., Zachary T. Long

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Computational modeling of 3D-printed Lactobacillus-antibiotic scaffolds for bacterial vaginosis., Veeresh P. Rai

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Development and evaluation of a body weight support treadmill for use with locomotor training on pediatric spinal cord injury patients., Winston T Rauch

Theses/Dissertations from 2020

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An exercise device used to achieve bone formation metrics for the strengthening of the proximal femur., Sean P. Coyle

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Mathematical characterization of a microfluidic ultrasound driven transfection device., Chris J. Holton

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Evaluation of tracing techniques in the rat spinal cord using a custom MATLAB application., Rachel M. Zalla

Theses/Dissertations from 2019

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A deep learning approach to detect diabetic retinopathy in fundus images., Winston R. Furtado

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Simulation of a continuum tumor model using distributed computing., Dylan A Goodin

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Feasibility study of intelligent LVAD control for optimal heart failure therapy., John A. Karlen III

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Non-viral transfection efficiencies for the advancement of CAR-T therapy., Emily M Murphy

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Suture-less Trocar Site Closure Clip, Hares A. Patel

Theses/Dissertations from 2018

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Optimization of PLGA and PLGA-dasatinib particles through a Taguchi design approach, Rayeanne N Balgemann

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Design and development of a multifunctional surgical device for ground and space-based surgical applications., Brooke Elaine Barrow

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Tumor-targeted double emulsions for ultrasound-triggered delivery of molecular therapeutics., Connor S Centner

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Investigation of cardiovascular tissue following 56Fe-radiation and potential countermeasure effectiveness., Alexandra R DeCarlo

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Biomechanical characterization of video-recorded short-distance falls involving children equipped with a biometric device: a pilot study., Bret A Hilt

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Restoring cholesterol homeostasis in familial hypercholesterolemia cell line model, Lubna Hindi

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The effectiveness of localized ultrasound and aptamer surface modification on nanoemulsions for drug delivery to spheroids., Daniel A. Hodge

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Investigating the likelihood of pediatric femur fracture due to falls through finite element analysis., Keyonna McKinsey

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PLGA-modified nanoparticles for the treatment of hypo-vascularized HPV-related cervical cancers., Lee B. Sims

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Rotary pump speed modulation to produce pulsatile flow and ventricular volume unloading., Connor Joseph Smith

Theses/Dissertations from 2017

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Development of a directional bone reaming system., Richard J Ackermann

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A novel MRA-based framework for the detection of changes in cerebrovascular blood pressure., Yitzhak Atakilt Gebru

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Custom software for the 3D printing of patient specific plate bending templates in pelvic fracture repair., Gordon B Lents

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Examining the effects of macrophage populations on cancerous tumor growth., Grace E. Mahlbacher

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Biomechanical testing of an exercise for strengthening the proximal femur., Alyssa Osbourne

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Design, development, and characterization of breathforce : a respiratory training system for patients with spinal cord injuries., Kevin L Tran

Theses/Dissertations from 2016

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Gamma-radiation exposure alters the cardiovascular extracellular matrix., Nicholas Allen

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Development and evaluation of custom prosthetic devices for a companion animal utilizing additive manufacturing., Benjamin Joseph Cahill

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Efficacy of subcutaneous electrocardiogram leads for synchronous timing and aortic root cannulation for chronic counterpulsation therapy., Stephen R. Carnahan

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Development of a novel device for ventricular assist device outflow graft anastomosis., Young Choi

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Foot strike patterns and body alignment effects on muscle activity during running., Nicole Knapp

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Fabrication, characterization and skin permeation of antoxidant-loaded lipid vesicles for transdermal drug delivery., Emily Martin

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Automated analysis of cancerous histological samples., Thomas Allen Tennill

Theses/Dissertations from 2015

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Novel biomechanical test method for cancellous bone screws and screw augmentation with cement., Kevin Lancaster

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Fibroblast-derived extracellular matrix: an alternative cell culture substrate that alters lung cancer cell line phenotype., Michael Thomas Scherzer

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Synthesis, optimization, and degradation of a fish glue/PLGA polymer., Adam T. Schworer 1989-

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Development of a neuromusculoskeletal computer model in a chondrodystrophic dog., Gregory Russo States

Theses/Dissertations from 2014

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Development of an application for patient-centered dementia care., David Collar Alston

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Synthesis of a drug delivery vehicle for cancer treatment utilizing DNA-functionalized gold nanoparticles., Tyler Brann

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Fabrication and characterization of antioxidant loaded liposomes., Brian Gettler

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Development of novel methods for analysis of autonomic balance and gamma coherence in autism., Marie Katherine Hensley

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Personalized anticoagulant management using reinforcement learning., Michael Jacobs

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Crosslinking albumin for drug release from spray dried particles., Ishita Jain

Theses/Dissertations from 2013

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Human powered Knudsen pump for pneumatic pharmaceutical delivery., Alexander Donovan Bell

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Development of a physiologic ex vivo vessel perfusion system., Mitchell J. Buller

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Evaluation of drug release from Abraxane and Doxil in tumor tissue., Michael Christopher Clark

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Biomodeling of pancreatic tumor mass., Justin Lee Howell

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Production of high yield gold/gold-sulfide nanoparticles via cellulose membrane., Kurtis T. James

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An improved thin-film microelectrode array and signal conditioning board for measuring cardiac surface potentials., Christopher Hayward Osborne

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Surface bound PEG-RGDS on PEG-DA hydrogels and its effects on RPE cell morphology and differentiation., Jeremy E. Phillips

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Development of novel layered nanoparticles for more efficient cancer treatment., Thomas A. Priest

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Apical left ventricular cannula sutureless implantation development., Adam D. Scarsella

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Force sensing glove for quantification of joint torques during stretching after spinal cord injury in the rat model., Erik Seibt

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Ventricular assist device and extracellular matrix combination therapy in a chronic ischemic heart failure bovine model., Erin F. Smith

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Automated testsystem of COGNISION headset for cognitive diagnosis., Joshua I. White

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Pulsatile flow does not improve efficacy in ex vivo lung perfusion., Keith A. Zoeller

Theses/Dissertations from 2012

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Removal of electrocardiographic corruption from electromyographic signals using a localized wavelet based approach., Nihit Bajaj

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Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media., Daniel Baumann

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Analysis of induced gamma oscillations with a data alignment technique in autism and attention deficit hyperactive disorder., Eric Gross

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Analysis of EEG rhythms using custom-made MatLab application for processing of data collected during neurofeedback training in ADHD subjects., Brent Hillard

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Carbon nanotube biosensors for detection of biomarkers in breast cancer cells., Benjamin C. King

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The VEGF quadruplex-forming sequence inhibits lung cancer cell growth., Edward David Muench 1987-

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A novel high yield process for gold sulfide nanoparticle synthesis via shifting equilibrium of self-assembly reaction., Dhruvinkumar Patel

Theses/Dissertations from 2011

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Quantification of vascular perfusion in the spinal cord after injury., Ruthie S. Fligor

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RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study., Mickey S. Ising

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Feasibility of subcutaneous ECG leads for synchronized timing of a counterpulsation device., Sean P. Warren

Theses/Dissertations from 2010

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Investigation of high-frequency ultrasound biomicroscopy for examining arteriopathy in hand transplant patients., Emily Renee Cox 1987-

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Treatment of severe aortic stenosis : experimental design, testing, and analysis of an aortic valve bypass apical cannula., Joel Douglas Graham

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Development of EEG gama indicies of cue reactivity to assess functional outcomes of neurofeedback training in substance use disorder., Timothy Joseph Horrell

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Shape-based detection of cortex variability for more accurate discrimination between autistic and normal brains., Matthew Joseph Nitzken 1987-

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Chitosan nanoparticles to encapsulate a biofilm degrading enzyme for treatment of CRBSI., Lindsay Nicole Strotman