Date on Master's Thesis/Doctoral Dissertation

5-2020

Document Type

Master's Thesis

Degree Name

M.S.

Department

Pharmacology and Toxicology

Degree Program

Pharmacology and Toxicology, MS

Committee Chair

Conklin, Daniel

Committee Co-Chair (if applicable)

Siskind, Leah

Committee Member

Siskind, Leah

Committee Member

Srivastava, Sanja

Committee Member

O'Toole, Timothy

Committee Member

D'Souza, Stanley

Author's Keywords

tobacco smoking; electronic cigarette; aldehyde; platelet activation; thrombosis; flavoring

Abstract

Cigarette smoking is the single largest risk factor for cardiovascular disease (CVD) pathophysiology. Numerous researchers have shown potential associations between aldehydes in tobacco-derived aerosols from mainstream cigarette smoke (MCS) or electronic cigarettes (e-cigs) and their cardiotoxicity by damaging blood vessel endothelium. The severity of exposure to these toxicants can furthermore lead to adverse cardiovascular outcomes such as myocardial infarctions, stroke, coronary and peripheral artery disease, or atherosclerosis due to blood clots, a pro-thrombotic event. However, the mechanisms by which levels of harmful and potentially harmful constituents (HPHCs) such as aldehydes induce thrombosis are not well-known. Of specific interest, evidence has shown that smoke exposure enhances platelet sensitivity and activation. Thus, the purpose of this project is to examine the effects of exposure to MCS, e-cigs, as well as their constituent saturated and unsaturated aldehydes, and flavoring additives on platelet activation as a marker of thrombosis.

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