Date on Master's Thesis/Doctoral Dissertation

8-2021

Document Type

Master's Thesis

Degree Name

M.S.

Department

Pharmacology and Toxicology

Degree Program

Pharmacology and Toxicology, MS

Committee Chair

Cave, Matthew

Committee Co-Chair (if applicable)

Clark, Barbara

Committee Member

Clark, Barbara

Committee Member

Hood, Jason

Committee Member

Kirpich, Irina

Committee Member

Prough, Russel

Committee Member

Rai, Shesh

Author's Keywords

PFAS; PFOS; ethanol; Lieber-DeCarli; fatty liver disease; metabolism disruption

Abstract

Perfluoroalkyl Substances (PFAS) are a family of man-made, surfactant-like compounds that are a major environmental contaminant. A multitude of studies have indicated that PFAS are able to induce fatty liver disease and modulate lipid metabolism. However, the distinct mechanism of PFAS influence on the liver and metabolism disruption remains to be elucidated. On the other hand, it is well documented that alcohol consumption has various adverse health impacts including fatty liver disease and subsequent progression to more adverse liver states. To date, there are no published studies on whether PFAS and alcohol can jointly exacerbate fatty liver progression or interact to disturb lipid metabolism. It is hypothesized that PFOS and alcohol will interact to exacerbate fatty liver but co-independently modulate metabolism. This study seeks to characterize the phenotype after male C57BL/6 mice are exposed to Perfluorooctanoic Sulfonate (PFOS), a prominent PFAS, while ad libitum consuming an alcohol diet.

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