Date on Master's Thesis/Doctoral Dissertation

12-2021

Document Type

Master's Thesis

Degree Name

M.S.

Department

Epidemiology and Population Health

Degree Program

Epidemiology, MSE

Committee Chair

Taylor, Kira

Committee Co-Chair (if applicable)

Baumgartner, Kathy

Committee Member

Baumgartner, Kathy

Committee Member

DeMarco, Daniel

Author's Keywords

COVID-19; depression; anxiety; Kentucky; mortality

Abstract

Previous studies have shown that mental disorders affect COVID-19 mortality. This study investigated the effect of depression and/or anxiety on COVID-19 outcomes. Depression/anxiety was defined by actively taking medication and/or diagnosis. The outcomes were ICU admission; ventilation; mortality; and time to mortality. Of 698 hospitalized patients, there were 204 (29%) defined to have either depression or anxiety. There were 109 deaths, and of those, 52 (48%) were diagnosed with depression/anxiety. Multivariable logistic regression and Cox proportional hazards models were used to examine associations. ICU admission and ventilation were not significantly associated with depression/anxiety. Depression/anxiety was associated with mortality (OR: 1.84, 95% CI: 1.15-2.93, p: 0.01) and time to mortality (HR: 1.60, 95% CI: 1.07-2.39, p: 0.02), adjusting for age, sex, and history of COPD. The association seemed driven by patients who were never admitted to the ICU. This study showed that depression/anxiety has a significant effect on COVID-19 mortality.

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