Date on Master's Thesis/Doctoral Dissertation
5-2022
Document Type
Doctoral Dissertation
Degree Name
Ph. D.
Department
Physiology and Biophysics
Degree Program
Physiology and Biophysics, PhD
Committee Chair
Galandiuk, Susan
Committee Co-Chair (if applicable)
Joshua, Irving
Committee Member
Joshua, Irving
Committee Member
Schuschke, Dale
Committee Member
Yan, Jun
Committee Member
Bhatnagar, Aruni
Committee Member
Maldonado, Claudio
Author's Keywords
colon cancer; macrophage; inflammation; metabolism; obesity; early-onset
Abstract
Early-onset colon cancer (EOCC) is a leading cause of cancer death among people younger than 50 years of age in the United States and is associated with metabolic dysfunction and obesity. Anti-inflammatory tumor-associated macrophages (TAM) and low Peroxisome Proliferator Activated Receptor Gamma (PPARγ) gene expression in colon cancer (CC) tissue promote tumor progression and decreased patient survival. Obesity-related hormones, such as leptin and adiponectin, have the potential to affect gene expression in TAM to promote CC progression and thereby link obesity and EOCC. The aim of this project was to identify target genes in human CC and to investigate the effects of leptin, adiponectin and the inflammatory macrophage metabolite itaconate on age- and obesity-related gene expression.
Recommended Citation
Scheurlen, Katharina Marietta, "The role of obesity in macrophage-mediated mechanisms promoting early-onset colon cancer." (2022). Electronic Theses and Dissertations. Paper 3850.
https://doi.org/10.18297/etd/3850
Included in
Medical Genetics Commons, Medical Immunology Commons, Neoplasms Commons, Oncology Commons
