Date on Master's Thesis/Doctoral Dissertation

8-2023

Document Type

Master's Thesis

Degree Name

M.S.

Department

Pharmacology and Toxicology

Degree Program

Pharmacology and Toxicology, MS

Committee Chair

Clark, Geoffrey J.

Committee Co-Chair (if applicable)

Donninger, Howard

Committee Member

Donninger, Howard

Committee Member

Beverly, Levi

Committee Member

Ceresa, Brian P.

Committee Member

Mitchell, Robert A.

Author's Keywords

RAS; Luminal B; breast cancer

Abstract

Historically, the RAS oncoprotein has not been implicated in breast cancer due to less than 1% of breast cancer cases bearing oncogenic RAS mutations. Recently, however, it has been reported that greater than 60% of Luminal B breast cancer cases have a decreased expression of negative RAS regulators RASAL2 and DAB2IP. Thus, in many Luminal B breast cancers, RAS remains in a constitutively active state without mutation, in turn driving oncogenesis. To date, there are no FDA-approved direct inhibitors of wild type RAS. We have developed a direct RAS inhibitor that acts on wild type RAS using in silico drug library screening. Using in vitro and in vivo model systems as proof-of-principle experiments, we have demonstrated our compound to inhibit anchorage-independent growth and RAS-mediated signaling in vitro, as well as decrease Luminal B cell tumor growth rate in vivo.

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