Date on Master's Thesis/Doctoral Dissertation
12-2023
Document Type
Master's Thesis
Degree Name
M.S.
Department
Pharmacology and Toxicology
Degree Program
Pharmacology and Toxicology, MS
Committee Chair
Huang, Jiapeng
Committee Member
Cai, Lu
Committee Member
Koukam, J. Calvin
Committee Member
Young, Jamie
Committee Member
Buchanan, Robert
Author's Keywords
Cadmium; pulmonary; arterial; hypertension
Abstract
We reported pulmonary artery hypertension (PAH) patients had elevated levels of Cd in both blood and urine, therefore, this study tested whether Cd directly induces PAH or facilitates PAH pathogenesis in mouse models. C57/6J mice were initially exposed to drinking water with or without 5ppm Cd for 8 weeks. Then, half the mice in both control and Cd groups were given SU5416 and hypoxia (SuHx) for 4 weeks to induce PAH, resulting in 4 subgroups: Control, Cd, PAH, and Cd+PAH. Diastolic and systolic functions of the left and right ventricles (LV, RV) were examined with echocardiography before and after PAH. Eight-week Cd exposure did not significantly change RV structure or systolic function. However, 12-week Cd exposure significantly increased RV systolic function, exacerbated PAH-associated RV dysfunction, and significantly increased structural remodeling in LV, RV, and lungs, although did not further exacerbate RV and lung remodeling in the setting of PAH.
Recommended Citation
Cathey, Dakotah Dominique, "Study of the effects of chronic cadmium exposure on the pathogenesis of pulmonary arterial hypertension." (2023). Electronic Theses and Dissertations. Paper 4194.
Retrieved from https://ir.library.louisville.edu/etd/4194
