Document Type

Article

Publication Date

7-3-2019

Department

Biology

Abstract

MitoNEET (gene cisd1) is a mitochondrial outer membrane [2Fe-2S] protein and is a potential drug target in several metabolic diseases. Previous studies have demonstrated that mitoNEET functions as a redox-active and pH-sensing protein that regulates mitochondrial metabolism, although the structural basis of the potential drug binding site(s) remains elusive. Here we report the crystal structure of the soluble domain of human mitoNEET with a sulfonamide ligand, furosemide. Exploration of the high-resolution crystal structure is used to design mitoNEET binding molecules in a pilot study of molecular probes for use in future development of mitochondrial targeted therapies for a wide variety of metabolic diseases, including obesity, diabetes and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Original Publication Information

Geldenhuys, W.J., Long, T.E., Saralkar, P. et al. "Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand." 2019 Communications Chemistry 2, 77: 1-9.

https://doi.org/10.1038/s42004-019-0172-x

DOI

10.1038/s42004-019-0172-x

ORCID

0000-0003-1072-5462

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Biology Commons

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