Document Type
Article
Publication Date
9-15-2022
Department
Medicine
Abstract
The role of catheter ablation in patients with atrial fibrillation (AF) in enhancing long-term outcomes remains unknown. This meta-analysis aimed to assess the impact of catheter ablation on stroke, all-cause mortality, hospitalization due to heart failure, and major bleeding events in patients with atrial fibrillation. This meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The data search was carried out by two authors independently using online databases including PubMed, EMBASE, and Cochrane library. The primary outcome was a stroke. The secondary outcomes were all-cause mortality, hospitalization for heart failure, and major bleeding events. Total, 10 articles were included in the current meta-analysis encompassing 275392 patients (33291 in the ablation group and 244974 in the non-ablation group). Among all included studies, one study was a randomized control trial, while the remaining other were retrospective cohorts. The current meta-analysis showed that catheter-based AF ablation reduced the risk of stroke (hazard ratio {HR}: 0.61, 95% CI: 0.49-0.77), all-cause mortality (HR: 0.60, 95% CI: 0.51-0.71), and hospitalization for heart failure (HR: 0.57, 95% CI: 0.43-0.76). No significant differences were reported in terms of major bleeding events between patients who received catheter-based AF ablation and patients who did not receive catheter-based AF ablation (HR: 0.96, 95% CI: 0.80-1.14). In the current meta-analysis, catheter-based AF ablation was associated with decreased risk of all-cause mortality, stroke, and hospitalization due to heart failure. However, no significant difference was reported in terms of major bleeding events.
Original Publication Information
Shaik T, Haseeb M, Faisal S, et al. (September 15, 2022) Impact of Catheter Ablation on Long-Term Outcomes in Patients With Atrial Fibrillation: A Meta-Analysis. Cureus 14(9): e29202.
ThinkIR Citation
Shaik, Tanveer Ahamad; Haseeb, Muhommad; Faisal, Sana; Obeidat, Kinan; Salam, Osama; Karedath, Jithin; Ganaie, Zubair Ahmed; and Hirani, Shamsha, "Impact of catheter ablation on long-term outcomes in patients with atrial fibrillation: A meta-analysis" (2022). Faculty and Staff Scholarship. 844.
https://ir.library.louisville.edu/faculty/844
DOI
10.7759/cureus.29202
ORCID
0000-0003-4972-0108
Comments
Published in Cureus, Journal of Medical Science v. 14, no. 9 (Sep. 2022)