Characterization of age-associated gut microbial dysbiosis and plasma metabolite alterations in people living with HIV (PLWH).

Authors

R. Sighal, University of Louisville
Smita Ghare, University of Louisville
Vaughn Bryant, University of Florida
Sabina Gautam, University of Louisville
Chanakya Charan Tirumala, University of Louisville
Andrea Reyes-Vega, University of LouisvilleFollow
Craig J. McClain, University of Louisville
Ronald Cohen, University of Florida
Varand Govind, University of Miami
R L. Cook
Shirish Barve, University of Louisville

Document Type

Article

Publication Date

4-1-2021

Department

Medicine

Abstract

Background: HIV-1 infection and aging are independently associated with gut microbial dysbiosis and neurocognitive impairment. However, the interactive effects of HIV-infection and aging on the development of specific pathogenic features of gut microbial dysbiosis and consequent metabolic abnormalities associated with neurocognitive dysfunction remain largely undetermined and were examined in the present study

Original Publication Information

Paper Abstract

ThinkIR Citation

Sighal, R.; Ghare, Smita; Bryant, Vaughn; Gautam, Sabina; Tirumala, Chanakya Charan; Reyes-Vega, Andrea; McClain, Craig J.; Cohen, Ronald; Govind, Varand; Cook, R L.; and Barve, Shirish, "Characterization of age-associated gut microbial dysbiosis and plasma metabolite alterations in people living with HIV (PLWH)." (2021). Faculty and Staff Scholarship. 962.
https://ir.library.louisville.edu/faculty/962

DOI

doi.org/10.1111/jgs.17115

ORCID

0000-0003-1633-6097