Characteristics and Outcomes of Adults Hospitalized with SARS-CoV-2 Community-Acquired Pneumonia in Louisville, Kentucky

Authors

Julio A. Ramirez, University of LouisvilleFollow
Jose Bordon, University of Louisville, Division of Infectious DiseasesFollow
Rodrigo Cavallazzi, University of LouisvilleFollow
Stephen P. Furmanek, University of LouisvilleFollow
Amr Aboelnasr, University of LouisvilleFollow
Mahder A. TellaFollow
William A. Mattingly, University of LouisvilleFollow
Ashley M. Wilde, Norton HealthcareFollow
Daisy SangroulaFollow
Demetra Antimisiaris, University of LouisvilleFollow
Donghoon Chung, University of LouisvilleFollow
Guillermo CabralFollow
Gabino R Fernandez-BotranFollow
Jiapeng HuangFollow
Martin GnoniFollow
Ozan Akca, Vice Chair, Professor, Department of Anesthesiology & Perioperative Medicine; Director, Stroke ICU, CSCRP, University of Louisville, Louisville, KYFollow
Paul Schulz, Infectious Diseases, Norton HealthcareFollow
Phillip F. Bressoud, University of LouisvilleFollow
Priya Krishnan, Robley Rex VA Medical CenterFollow
Sally Suliman, University of Louisville, School of MedicineFollow
Sathya Krishnasamy, University of Louisville, School of MedicineFollow
Stephen S. Hanson, University of LouisvilleFollow
William P. McKinney, University of LouisvilleFollow
Harpal Sandhu, University of LouisvilleFollow
Leslie A WolfFollow
Mark Burns, University of Louisville, Louisville, KYFollow
Ruth CarricoFollow
Forest W. Arnold, University of LouisvilleFollow

20.0257

Funder

The author(s) report no funding was provided for this work.

Abstract

Background: Patients infected with the novel coronavirus SARS-CoV-2 are frequently hospitalized with community-acquired pneumonia (CAP). The objective of this study was to define the clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 CAP in the city of Louisville, KY.

Methods: This was a retrospective observational study of 700 patients with SARS-CoV-2 infection hospitalized at eight of the adult hospitals in the city of Louisville. Patients with 1) a positive RT-PCR for SARS-CoV-2, 2) fever, cough, or shortness of breath, and 3) an infiltrate on chest imaging were defined as having SARS-CoV-2 CAP. Demographic characteristics of the study population were compared with census data from the city of Louisville. For each patient, more than 500 variables were abstracted from electronic medical records and recorded using Research Electronic Data Capture software. Data were analyzed by descriptive and inferential statistics using R version 3.4.0.

Results: SARS-CoV-2 CAP was identified in 632 (90%) patients hospitalized with COVID-19. The median age of the patients was 63 years, 53% were females, 31% were black, and 12% were Hispanic. The most frequent comorbidities were hypertension (56%), obesity (50%), and diabetes (33%). Mortality was 17% for the total population and 34% for the 249 patients admitted to ICU. For each category of race, ethnicity, or comorbidity, the proportion of hospitalized patients with SARS-CoV-2 CAP was significantly different compared to the Louisville population (P<0.001).

Conclusion: Patients of black race, Hispanic ethnicity, and patients with a history of hypertension, obesity, or diabetes are overrepresented among hospitalized patients with SARS-CoV-2 CAP compared to the Louisville population. Hospitalized patients with SARS-CoV-2 CAP are likely to require ICU care, with death occurring in approximately one of six hospitalizations.

DOI

10.18297/jri/vol4/iss1/72

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Ramirez, Julio A.; Bordon, Jose; Cavallazzi, Rodrigo; Furmanek, Stephen P.; Aboelnasr, Amr; Tella, Mahder A.; Mattingly, William A.; Wilde, Ashley M.; Sangroula, Daisy; Antimisiaris, Demetra; Chung, Donghoon; Cabral, Guillermo; Fernandez-Botran, Gabino R; Huang, Jiapeng; Gnoni, Martin; Akca, Ozan; Schulz, Paul; Bressoud, Phillip F.; Krishnan, Priya; Suliman, Sally; Krishnasamy, Sathya; Hanson, Stephen S.; McKinney, William P.; Sandhu, Harpal; Wolf, Leslie A; Burns, Mark; Carrico, Ruth; and Arnold, Forest W. (2020) "Characteristics and Outcomes of Adults Hospitalized with SARS-CoV-2 Community-Acquired Pneumonia in Louisville, Kentucky," The University of Louisville Journal of Respiratory Infections: Vol. 4 : Iss. 1 , Article 72.
DOI: https://doi.org/10.18297/jri/vol4/iss1/72
Available at: https://ir.library.louisville.edu/jri/vol4/iss1/72