Efficacy of Convalescent Plasma and Short Course of Corticosteroids in Patients with COVID-19

Authors

Srikanth Ramachandruni, CHRISTUS Spohn Health SystemFollow
Po-Yang Tsou, Department of Pediatrics and Pediatric Critical Care, Driscoll Health System, Corpus Christi, TX. USAFollow
D.C. Benetez, Department of Infectious Disease and Department of Pulmonary Critical Care, CHRISTUS Spohn Health System, Corpus Christi, TX, USAFollow
Gayathri Evani, University of Texas, San AntonioFollow
Smitha Gudipati, Henry Ford Health SystemFollow
Ramakrishna Chakilam, Department of Infectious Disease and Department of Pulmonary Critical Care, CHRISTUS Spohn Health System, Corpus Christi, TX, USAFollow
Polly Mock, CHRISTUS Spohn Health SystemFollow
Bharat Narasimhan, Icahn School of Medicine, Mount Sinai, New York, NY, USAFollow
Dhanunjay Lakkireddy, Kansas City Heart Rhythm Institute and research foundation, Overland Park, KS, USAFollow
Shekhar Raj, Department of Pediatrics and Pediatric Critical Care, Driscoll Health System, Corpus Christi, TX. USAFollow

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Funder

The author(s) received no specific funding for this work.

Abstract

This study reported the efficacy of short-course corticosteroids and convalescent plasma (CP) transfusion in treating five patients with severe COVID-19 disease. Five adults (mean±standard deviation age: 70±9 years) with laboratory-confirmed COVID-19 and severe hypoxemia (PaO₂/FiO₂ [P/F]<100) requiring invasive mechanical ventilation received five days methylprednisolone (40 mg intravenously every 12 hours) and subsequent CP transfusion (250–400 ml). Compared with the baseline, P/F ratios increased by 46% and by 28% after short course corticosteroids and CP transfusion, respectively. Four patients survived. Short-course corticosteroids and CP transfusion may improve hypoxemia in patients with severe COVID-19 disease.

DOI

10.18297/jri/vol4/iss1/8

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Ramachandruni, Srikanth; Tsou, Po-Yang; Benetez, D.C.; Evani, Gayathri; Gudipati, Smitha; Chakilam, Ramakrishna; Mock, Polly; Narasimhan, Bharat; Lakkireddy, Dhanunjay; and Raj, Shekhar (2020) "Efficacy of Convalescent Plasma and Short Course of Corticosteroids in Patients with COVID-19," The University of Louisville Journal of Respiratory Infections: Vol. 4 : Iss. 1 , Article 8.
DOI: https://doi.org/10.18297/jri/vol4/iss1/8
Available at: https://ir.library.louisville.edu/jri/vol4/iss1/8