This study reported the efficacy of short course corticosteroids and convalescent plasma (CP) transfusion in treating five patients with severe COVID-19 disease. Five adults (mean age: 70 ± 9 years) with laboratory-confirmed COVID-19 and severe hypoxemia (PaO2/FiO2 [P/F]<100) requiring invasive mechanical ventilation received 5-days methylprednisolone (40 mg intravenously every 12 hours) and subsequent CP transfusion (250-400 ml). Compared with the baseline, P/F ratios increased by 46% and by 28% after short course corticosteroids and CP transfusion. Four patients survived. Short course corticosteroids and CP transfusion may improve hypoxemia in patients with severe COVID-19 disease.
The author(s) received no specific funding for this work.
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Ramachandruni, Srikanth; Tsou, Po-Yang; Benetez, D.C.; Evani, Gayathri; Gudipati, Smitha; Chakilam, Ramakrishna; Mock, Polly; Narasimhan, Bharat; Lakkireddy, Dhanunjay; and Raj, Shekhar
"Efficacy of Convalescent Plasma and Short Course of Corticosteroids in Patients with COVID-19,"
The University of Louisville Journal of Respiratory Infections: Vol. 4
, Article 8.
Available at: https://ir.library.louisville.edu/jri/vol4/iss1/8