Hyaluronan Modulated Expression of MMPs 2, 9, and 12 in Macrophages

Authors

Jeffrey S. Miller, University of LouisvilleFollow
Caitlin Howard, University of LouisvilleFollow
Steven P. Jones PhD, University of LouisvilleFollow

Program/Event

Undergraduate Research Showcase Spring 2023

Abstract

Hyaluronan (HA) is a ubiquitously expressed Glycosaminoglycan (GAG) found as a main component of the extracellular matrix (ECM). Matrix metalloproteases (MMPs) are class of enzyme responsible for the degradation of multiple ECM components, including HA. Following a myocardial infarction (MI), ECM remodeling occurs in the infarct tissue and involves an accumulation of HA. Remodeling is facilitated by multiple cell types, including macrophages. During post-MI ECM remodeling, macrophages degrade and ingulf dead cells and ECM components, a process which requires the expression of MMPs. MMPs 2, 9, and 12 are known to be elevated post-MI; MMPs 9 and 12 are known to have HA as a substrate. These factors make MMPs 2, 9, and 12 especially relevant to the post-MI ECM remodeling process. The effect of increased HA present post-MI on levels of MMP expression in macrophages has yet to be investigated.

Recommended Citation

Miller, Jeffrey S.; Howard, Caitlin; and Jones, Steven P. PhD (2021) "Hyaluronan Modulated Expression of MMPs 2, 9, and 12 in Macrophages," The Cardinal Edge: Vol. 1: Iss. 4, Article 23.
Available at: https://ir.library.louisville.edu/tce/vol1/iss4/23