Abstract
Aging is a complex process influenced by various cellular mechanisms, with several distinctive features associated with its progression. Among the hallmarks of aging is the loss of proteostasis, or disruption in the balance of proteins within the cell. Recent research has made significant strides in unraveling the intricate relationship between proteostasis and aging. Notably, studies have demonstrated that decreased protein synthesis can extend the healthspan of organisms. Moreover, inhibition of mechanistic target of rapamycin (mTOR) complex 1 has been shown to selectively reduce the lifespan limiting proteins while promoting autophagy, thereby extending organismal lifespan. Thus, this paper aims to review the current literature in this field and examine the recent research advancements in the therapeutic targeting of proteostasis to mitigate the effects of aging. Furthermore, it will discuss potential future directions, as well as current challenges within this promising area of anti-aging research.
Recommended Citation
Jackel, Christopher A.
(2024)
"The Relationship Between Protein Synthesis and Aging,"
The Cardinal Edge: Vol. 2:
Iss.
1, Article 15.
Available at:
https://ir.library.louisville.edu/tce/vol2/iss1/15
