Program/Event
Arts and Research Showcase 2024
Abstract
Breast cancer is one of the most common cancers diagnosed in adults, with 2.3 million new cases worldwide in 2020. Plants have been used in traditional medicine and are a potential source of pharmaceuticals. One example is the large Lamiaceae (mint) family. The Salvia genus, commonly known as the sages, is the largest genus in Lamiaceae with almost 900 known species. Different species of salvia are found in parts of the US, and some have a history in traditional medicine to treat cancers and other ailments. Preliminary research on three salvia species (S. lyrata, S. lyrata var. Purple Knockout, and Salvia officinalis) revealed potent anticancer activity in the leaves of S. officinalis (common sage) and moderate activity in S. lyrata. The triple-negative breast cancer cell line, MDA-MB-231, was impacted most between three breast cancer cell lines assayed. To expand upon these findings, acid hydrolysis was also employed to remove glycosides and thus influence extract polarity, and the potential for acid hydrolysis to increase antiproliferation activity was assayed. Acid hydrolysis increased the anticancer activity of S. officinalis in the T-47D cell line. Compounds were identified with high-performance liquid-chromatography (HPLC) and gas-chromatography paired with mass spectrometry (GC-MS). Salvia contains many different phenolic compounds, some of which have been found to have anticancer activity. Once active biomolecules were identified, the antiproliferation activity of specific isolated biomolecules was assayed, and luteolin and apigenin were found to have the greatest anticancer activity of the phenolic compounds tested against the MDA-MB-231 and T-47D cell lines.
Recommended Citation
Portaro, Allison C.; Scott, Jared L.; and Schultz, David J.
(2024)
"Assessing the Bioactivity of Salvia Phytochemicals Against Breast Cancers,"
The Cardinal Edge: Vol. 2:
Iss.
2, Article 14.
Available at:
https://ir.library.louisville.edu/tce/vol2/iss2/14
