This collection includes theses and dissertations from the Department of Pharmacology and Toxicology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please see: http://ir.library.louisville.edu/about.html.

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Theses/Dissertations from 2011

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Profile of systemic treatment with the antiviral lectin Griffithsin in guinea pigs., Christopher Lynn Barton 1976-

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Mechanistic insights into copper-induced regression of heart hypertrophy., Katherine Bourcy

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Prevention and treatment of lung cancer by green tea polyphenols., Pengxiao Cao

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Adenovirus-induced cyclin E activates CDK2 for virus replication., Pei-Hsin Cheng 1983-

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Searching for novel ligands for the cannabinoid and related receptors., Pritesh Prakash Kumar 1986-

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Role of HDACs and SAM in interferon-alpha signaling and epigenetic regulation of anti-HCV gene expression., Stephanie A. Mathews

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Functional analysis of N-acetyltransferase (NAT1*14B and NAT1*10) in complete NATb and NATa mRNA., Lori Michele Millner

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Mitigating cisplatin resistance in ovarian cancer., Clarisse S. Muenyi

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Arsenic-induced developmental changes in the liver and adult cardiovascular disease., Ntube Nini Olive Ngalame

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Pharmacists as mid-level healthcare providers and the clinical results of a pharmacist-led diabetes disease management program., Benjamin Maurice Risner 1983-

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The role of curcumin in response to BPDE-induced DNA damage in human lung epithelial cells., Erica Nicole Rogers

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Sulforaphane prevents acetaminophen-induced hepatic injury in mice., Robin H. Schmidt 1984-

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DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage., Lindsey Jay Stallons 1983-

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Cardiac abnormalities after transaortic constriction are worsened by changing glucose metabolism and benefited by repair of mitochondrial DNA., Jianxun Wang 1969-

Theses/Dissertations from 2010

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The role of genetic and environmental oxidative stress factors in prostate cancer., Nicole A. Lavender

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Functional effects of CYP1A2, NAT1, and NAT2 genetic variants in nucleotide excision repair-deficient human fibroblasts : implications for toxicological risk from environmental arylamines., Carmine Simone Leggett

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Curcumin reactivates epigenetically silenced tumor suppressor gene tissue factor pathway inhibitor-2 in hepatocellular carcinoma cells., Akshata Moghe 1983-

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Cigarette smoke, DNA damage and repair in human cervical and vaginal cells in vitro and ex vivo., Afsoon Moktar

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Adriamycin nephrotoxicity is reduced by metallothionein over-expression and kidney gene expression is modified by diabetes in the OVE26 diabetic model., Lu Yang

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Arsenic in drinking water causes gene expression changes in the liver related to inflammation and metabolic dysfunction and accelerates atherosclerosis in ApoE-/-mice, Matthew R. Zajack

Theses/Dissertations from 2009

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The role of PKC-epsilon in models of alcohol- and toxin-induced liver disease., J. Phillip Kaiser 1981-

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Mechanisms mediated by CXCL12 signaling through CXCR4 and CXCR7 in breast cancer., LaSharon Denise Mosley

Theses/Dissertations from 2008

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The role of Hsp90 in PC-12 cell survival., Christina Blume Clark

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The use of the reducing agent N-(2-Mercaptopropionyl)glycine to detoxify oxidized lipids in atherosclerotic lesions., Nason P. Schooler 1974-

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Mutagenic and tumor suppressor functions of DNA polymerase iota in mammalian cells., Lindsey Jay Stallons 1983-

Theses/Dissertations from 2007

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Participation of mouse DNA polymerases iota, eta, and rev1 in translesion synthesis of carcinogen induced DNA adducts and carcinogenesis., Chad Aaron Dumstorf 1977-

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The changes of fructos-2,6-bisphosphate level in transgenic mice causing cardiomyopathy., Jianxun Wang 1969-

Theses/Dissertations from 2006

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Mechanism of 4-Hydroxynonenal induced toxicity in Jurkat CD4+ T lymphocytes., Wei Yuan Chang

Theses/Dissertations from 2005

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Investigations of N-acetyltransferases in human hepatocytes and rat models., Jason Matthew Walraven

Theses/Dissertations from 2004

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The role of nuclear factors of activated T-cells (NFAT) in neuronal death., Agata M. Habas 1976-

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The roles of pancreatic beta cell antioxidants in islet transplantation and type 1 diabetes., Xiaoyan Li

Theses/Dissertations from 2003

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Studies of the effects of pancreatic beta cell antioxidant transgenes on experimental models of diabetes., Hainan Chen

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Oxygen toxicity and mitochondrial metabolism., Jian Li 1974-

Theses/Dissertations from 2002

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Metallothionein overexpression prolongs grafts survival in the early phase of pancreatic islet transplantation., Xiaoyan Li

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Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy., Xia Shen 1976-

Theses/Dissertations from 1945

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Studies on spinal anesthesia., Frederic E. Shaffer

Theses/Dissertations from 1937

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The effect of splenectomy on the differential cell count of the anterior pituitary in relation to post-splenectomy changes in the blood picture of the dog., Herbert J. Brinker