This collection includes theses and dissertations from the Department of Pharmacology and Toxicology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.
Theses/Dissertations from 2024
Preclinical stability assessment of EPICERTIN, a biotherapeutic candidate for ulcerative colitis mucosal healing., Wendy Michelle Kittle
Investigation of Avaren-Fc's therapeutic potential against ovarian cancer., Katarina Lee Mayer
Theses/Dissertations from 2023
Effects of environmental pollutants on liver disease: role of the gut-liver axis., Ngozi Victoria Adiele
Investigating the effects of subchronic dietary zinc supplementation on diet-induced metabolic dysfunction-associated steatotic liver disease., Oluwanifemi Esther Bolatimi
Study of the effects of chronic cadmium exposure on the pathogenesis of pulmonary arterial hypertension., Dakotah Dominique Cathey
Environmental exposures and aging., Daniel Chris Gomes
The impact of environmental pollutants on alcohol-associated liver disease pathogenesis., Tyler Charles Gripshover
KDM5B as a potential epigenetic regulator of cardiomyocyte regeneration and cell cycle activation., Dana Hammouri
Inhibition of RAS as a novel therapeutic approach in Luminal B breast cancer., Raphael Ngozichi Jigo
Lung cancer-kidney crosstalk enhances cisplatin-induced nephrotoxicity., Andrew Orwick
Epicertin: preclinical development of a novel mucosal healing agent for ulcerative colitis., Micaela Reeves
Using a toxic aging coin to assess hexavalent chromium-induced neurotoxicity., Samuel Thomas Vielee
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy for alcohol-associated liver disease., Jeffrey Warner
Ethanol dysregulates Sirt1-mediated lipogenic signaling pathways through α4*-nicotinic acetylcholine receptors in hepatocytes., Caitlin Christina Wilkerson
Theses/Dissertations from 2022
The impact of PEGylation on cellular uptake and in vivo biodistribution of gold nanoparticle MRI contrast agents., Nagwa El-Baz
The effect of volatile organic compounds on endothelial function and atherogenesis., Samantha McFall
A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller
Tobacco-derived aldehydes, platelets, and thrombogenicity: role of transient receptor potential ankyrin-1., Andre D. Richardson
Cannabinoids and retinal fibrotic disorders., Lucy June Sloan
HGF-mediated c-met signaling in human corneal epithelial cells., Kate Tarvestad
The impact of volatile organic compound exposure on subclinical biomarkers of cardiovascular injury., Breandon Taylor
Molecular mechanisms of hexavalent chromium-induced centrosome amplification., Jennifer Haruka Toyoda
The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt
Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams
Theses/Dissertations from 2021
Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri
Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent
Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism., Marc Matthew Dwenger
PDE4 inhibition: a novel therapeutic strategy in liver fibrosis., Mohamed Elnagdy
Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model., Tyler Charles Gripshover
The role of sphingolipids in AKI and the progression to CKD: potential therapuetic targets., Nicholas A. Hoffman
Assessing the role of chronic arsenite exposure in disrupting the EGFR signaling axis., Christine Kim
The role of Src in NSCLC cell and lung fibroblast migration on 3D cell-derived matrix., Austin M Krueger
Assessing the role of arsenic exposure and MIRNA-186 in skin tumorigenesis and chromosomal instability., Angeliki Lykoudi
Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury., Andrew Joseph Orwick
Role of KVβ2 subunits in regulation of resistance arterial tone., Sean M Raph
Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis., Micaela Ann Reeves
Characterizing the role of macrophages in cisplatin-induced kidney injury and progression to chronic kidney disease., Sophia M. Sears
Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance., Kennedy M. Walls
Oligodendrocyte responses after spinal cord injury., George Zach Wei
Theses/Dissertations from 2020
Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle
N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil
A novel role for RASSF1A in the regulation of RAS activation., Desmond Ramón Harrell Stewart
Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li
Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch
Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng
Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson
Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner
The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young
Theses/Dissertations from 2019
Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent
Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin
Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga
Development of BAR-peptide nanoparticles and electrospun fibers for the prevention and treatment of oral biofilms., Mohamed Yehia Mahmoud
A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease., Joshua Mark Royal
Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system., Douglas John Owulaku Saforo
Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury., Sophia M. Sears
Cannabidiol, behavior, and immune biomarkers in idiopathic autism spectrum disorder., Sarah Huang Shrader
Electrospun fibers and nanoparticles for the prevention of sexually transmitted infections., Kevin Michael Tyo
Paraoxonase 2 is critical for non-small cell lung carcinoma proliferation., Aaron Whitt
Theses/Dissertations from 2018
Loss of the Na+/H+ exchange regulatory factor 1 results in increased susceptibility to cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle
Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach., Samantha Marie Carlisle
The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet., Liya Chen
Maturation of human induced pluripotent stem cell derived engineered cardiac tissues using chief transfection and chronic optical pacing., Marc M. Dwenger
A cancer-targeted gold nanoparticle-based MRI contrast agent., Nagwa El-Baz
EGFR signaling from the early endosome., Julie A. Gosney
Assessing the role of arsenite in disrupting the EGFR signaling axis., Christine Kim
Vinyl chloride enhances diet-induced liver injury via metabolic dyshomeostasis : critical role of mitochondria., Anna L. Lang
A study of GPR3, GPR6, of GPR12 as novel molecular targets for cannabidiol., Alyssa S. Laun
The role of cathelicidin in the regulation of gut microbiota and inflammasome activation in alcoholic liver disease., Fengyuan Li
Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age., Ryan Carroll McAllister
Evaluation of drug-loaded gold nanoparticle cytotoxicity as a function of tumor tissue heterogeneity., Hunter Allan Miller
Influence of bilberry-derived anthocyanidins on key regulators of colorectal cancer development., Ashley M. Mudd
Wnt/β-Catenin mediated cancer stem cell activation in hepatocellular carcinoma., Harshulkumar M. Pandit
Therapeutic potential of a plant-made cholera toxin b subunit variant for the treatment of ulcerative colitis., Joshua Mark Royal
Epidermal growth factor-like ligands regulate dimer selection., Jamie S. Rush
A clinically relevant mouse model of cisplatin-induced kidney injury., Cierra Nichole Sharp
Particulate hexavalent chromium does not induce centrosome amplification in sperm whale and bowhead whale cells., Jennifer Haruka Toyoda
Theses/Dissertations from 2017
MiRNA expression changes in arsenic-induced skin cancer in vitro and in vivo., Laila Al-Eryani
The effects of moderate alcohol consumption and inflammation on the hepatic matrisome and the renal cortex proteome., Christine E. Dolin
Sphingolipids in models of kidney disease and injury., Tess V. Dupre
Age-related host factors regulate lung cancer progression., John Caleb Greenwell
Targeting the glucose metabolism of myeloid-derived suppressor cells (MDSCs) to stimulate cancer immunity., Jaspreet Grewal
Targeting the major regulator of mitosis., J. Mason Hoffman
Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy., Elizabeth Marie Hollis
Identifying the signaling mechanisms of EGFR-mediated apoptosis., Nicole Marion Jackson
Advances in tumor-targeted therapy using nanomedicine., Divya Karukonda
