The Cardinal Edge


Dentinogenesis imperfecta (DI) is a genetic disorder characterized by dentin discoloration, tooth development irregularities, and decreased tooth strength. This autosomal dominant disorder is identified in individuals of all ages. There are three classifications of dentinogenesis imperfecta, each with varying presentations and causes. This report covers normal tooth development (odontogenesis), DI development, DI classifications, and the genes involved in this genetic disorder.