Angiogenesis plays a major role in the development of diseases and cancer. The development of illnesses like metastatic breast cancer, cell carcinomas, tumors and various other illnesses, originate from the activation of endothelial cells. When the vascular endothelial growth factor (VEGF) is released from hypoxic tissues, they bind to vascular endothelial growth factor receptors (VEGFR). The binding of VEGF and VEGFR allows for cellular proliferation, increased migration of lattice networks, and the invasion of endothelial cells, which stimulate the formation of new blood vessels from pre-existing ones. As a result, it can be concluded that the inhibition of VEGFs would interrupt the growth of tissues that are pathogenic, like in various cancers and diseases. Many therapies utilizing angiogenesis inhibitors are being used as a treatment method in clinical trials and for patients with various medical conditions. Angiogenesis inhibitors known to the market include monoclonal antibodies that are made in laboratories and various foods that exhibit angiogenic properties, the most well-known of which is green tea.
"Angiogenesis' effect overall on Health and Disease,"
The Cardinal Edge: Vol. 1, Article 25.
Available at: https://ir.library.louisville.edu/tce/vol1/iss1/25