This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.
Theses/Dissertations from 2020
Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis., Dylan MacGregor Johnson
Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li
Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch
Hearing loss: investigating the comfort, confidence, knowledge, and preparedness of Kentucky school-based speech-language pathologists., Amanda Matsumoto
Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng
The emerging oral pathogen, filifactor alocis, disrupts neutrophil functions to enhance survival and dysregulate inflammation., Irina Miralda Molina
Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems., Robert Chandos Monsen
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through NF-Kβ dependent glycolytic metabolic reprogramming., Samantha M. Morrissey
Modulation of inflammatory pathway by inflammatory inhibitor JSH-23 mitigates diabetic retinopathy., Rubens Petit Homme
Modulation of host innate immune cells by Yersinia pestis to create a permissive environment for replication., Amanda Rose Pulsifer
Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson
Identification and structural characterization functional motifs in the Porphyromonas gingivalis MFA1 short fimbria., Mohammad K. Roky
Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses., Pradeep Shrestha
Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer
Tissue-resident myeloid-derived suppressor cells modulate immune homeostasis in healthy adipose., Katlin Brooke Stivers
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner
The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young
Theses/Dissertations from 2019
A distinct pattern of sterile inflammation induced by zinc oxide nanowires., Ruqaih Salem Alghsham
Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent
Understanding object motion encoding in the mammalian retina., Victor Julian DePiero
Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin
Inspiratory muscle recruitment during swallow and a comparison across airway behaviors., Allison V. English
Alterations in rhythmic licking behaviors following fibrosis in the rat mylohyoid muscle., Brittany Fletcher
Coordination of airway protective behaviors and swallow: effects of afferent feedback and sex., Alyssa D. Huff
The effects of nicotine and cigarette smoking on cardiac electrophysiology., Affan B. Irfan
Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga
Development of BAR-peptide nanoparticles and electrospun fibers for the prevention and treatment of oral biofilms., Mohamed Yehia Mahmoud
Preference for odor-taste mixtures is dependent on previous experience., Kelsey Allison McQueen
Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression., Stephanie Metcalf
Glycine receptor expression across identified retinal ganglion cell types., Ian Scot Pyle
A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease., Joshua Mark Royal
Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system., Douglas John Owulaku Saforo
Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury., Sophia M. Sears
The self-efficacy of biological mothers and foster mothers caring for infants prenatally exposed to drugs or treated for NAS : examination of potentially influencing factors., Megan Kathleen Sherehiy
Cannabidiol, behavior, and immune biomarkers in idiopathic autism spectrum disorder., Sarah Huang Shrader
The effect of spinal cord injury on sexual function., Casey J. Steadman
Electrospun fibers and nanoparticles for the prevention of sexually transmitted infections., Kevin Michael Tyo
The manipulation of host transcription by the ANKH effector of legionella., Juanita E. Von Dwingelo
Paraoxonase 2 is critical for non-small cell lung carcinoma proliferation., Aaron Whitt
Theses/Dissertations from 2018
Nutritional virulence of Legionella pneumophila., Ashley M. Best
Unfolded protein response pathways in skeletal muscle homeostasis., Kyle R. Bohnert
Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach., Samantha Marie Carlisle
The migration and developmental remodeling of intrinsic interneurons in visual thalamus and the role of retinal signaling., Naomi E. Charalambakis
The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet., Liya Chen
Functional and structural impact of the loss of the leucine-rich repeat protein LRIT1 in the mouse retina., Catherine Ann Cobb
CD11b regulation of B cell receptor signaling in health and systemic lupus erythematosus., Paul Lorenzo Dascani
Characterizing the gut microbiota during plasmodium infection and antimalarial treatment., Joshua E. Denny
Maturation of human induced pluripotent stem cell derived engineered cardiac tissues using chief transfection and chronic optical pacing., Marc M. Dwenger
A cancer-targeted gold nanoparticle-based MRI contrast agent., Nagwa El-Baz
The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation., Jon David Faughn
Traumatic brain injury : investigating misconceptions among graduate students in physical therapy, occupational therapy, and speech-language pathology., Michael Frazure
EGFR signaling from the early endosome., Julie A. Gosney
Epidermal growth factor receptor (EGFR) inhibition by polychlorinated biphenyls contributes to non-alcoholic fatty liver disease (NAFLD)., Josiah Hardesty
Inflammasome independent leukotriene-b4 production drives crystalline silica induced sterile inflammation., Bindu Hegde
Autism spectrum disorder : investigating predictive diagnostic relationships in children three years-of-age and younger., Kaitlin Juergensen
Swallow and breathing coordination following suprahyoid muscle injury., Bradley Kimbel
Assessing the role of arsenite in disrupting the EGFR signaling axis., Christine Kim
Vinyl chloride enhances diet-induced liver injury via metabolic dyshomeostasis : critical role of mitochondria., Anna L. Lang
A study of GPR3, GPR6, of GPR12 as novel molecular targets for cannabidiol., Alyssa S. Laun
Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy., Avisek Majumder
Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age., Ryan Carroll McAllister
A new surgical approach for O-C2 fusion, solving the problem of dysphagia., M. Kathryn McClure
Evaluation of drug-loaded gold nanoparticle cytotoxicity as a function of tumor tissue heterogeneity., Hunter Allan Miller
Influence of bilberry-derived anthocyanidins on key regulators of colorectal cancer development., Ashley M. Mudd
Alpha-amino methylation and acetylation are novel regulators of MYL9 function., Christopher David Nevitt
Cholesterol metabolism and statin effects on an FH class II LDL-receptor mutation., Linda Omer
Wnt/β-Catenin mediated cancer stem cell activation in hepatocellular carcinoma., Harshulkumar M. Pandit
Divergent evolution of di-lysine ER retention vs. farnesylation motif-mediated anchoring of the ankb virulence effector., John David Perpich
Role of TrkB-signaling in taste development and function., Jennifer Rios-Pilier
Therapeutic potential of a plant-made cholera toxin b subunit variant for the treatment of ulcerative colitis., Joshua Mark Royal
Epidermal growth factor-like ligands regulate dimer selection., Jamie S. Rush
Characterization of type II toxin anti-toxin systems in Aggregatibacter actinomycetemcomitans., Blair W. Schneider
Feeding behaviors and the child with posterior tongue-tie : comparison to norms., McKenzie Sexton
A clinically relevant mouse model of cisplatin-induced kidney injury., Cierra Nichole Sharp
Investigating the impact of NRMT1 cancer mutants on catalytic specificity and the DNA damage response., Kaitlyn Marie Shields
Organization and development of cholinergic input to the mouse visual thalamus., Guela Sokhadze
Canonical nuclear factor-κB signaling in satellite stem cell homeostasis and function., Alex R. Straughn
Exercise preconditioning and TFAM overexpression diminish skeletal muscle atrophy., Nicholas Todd Theilen
Particulate hexavalent chromium does not induce centrosome amplification in sperm whale and bowhead whale cells., Jennifer Haruka Toyoda
Characterizing the virulence factor YapE in Yersinia pestis., Tiva Templeton VanCleave
Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity., Alexis Avidan Vega
The involvement of epithelial cells in arenavirus-induced pathogenesis., Nikole Leslie Margaret Warner
Tissue engineered micro and macrovasculature utilizing stromal vascular fraction., Joseph Samir Zakhari
Theses/Dissertations from 2017
MiRNA expression changes in arsenic-induced skin cancer in vitro and in vivo., Laila Al-Eryani
Characterization of Filifactor alocis and its immune evasion strategies employed against human neutrophils., Cortney Linn Armstrong
Enhancing cell therapy for ischemic cardiomyopathy., Michael J. Book
Neural coding of natural and synthetic speech., Allison Brown
PCB-associated steatohepatitis and the role of nuclear receptors., Heather Brooke Clair
Spinal cord injury induced cardiac decline and the limitations of exercise., Kathryn Michele DeVeau
