This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2015

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Role of c-Kit in the growth, migration and differentiation of human cardiac progenitor cells., Bathri Narayan Vajravelu

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Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury., Patrick Van Hoose

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Improved oncolytic virotherapy by increasing virus spread within tumors., Stephen Wechman

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Functional characterization of Aggregatibacter actinomycetemcomitans QSEBC : a bacterial adrengeric receptor and global regulator of virulence., Whitney Weigel

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Exercise mitigates the effects of hyperhomocysteinemia on adverse skeletal muscle remodeling., Lee Winchester

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Circulating angiogenic stem cells in diabetes., Nagma Zafar

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Glycine receptor alpha subunit (GlyRa) specific inhibition contributes to ganglion cell signaling in mouse retina., Chi Zhang

Theses/Dissertations from 2014

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The role of pesticides in non-alcoholic fatty liver disease (NAFLD)., Laila Al-Eryani 1986-

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Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis., Diana Veronica Avila

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MiRNA-21 has anti-inflammatory effects in the macrophage response to peritonitis., Rebecca Elise Barnett

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Evaluation of the safety and pharmacokinetic profile of the broad spectrum antiviral lectin Griffithsin., Christopher Lynn Barton

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Augmentation of Ras-induced cell transformation : a new role for miR-200a in malignancy., Lindsey Erin Becker

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Modulation of host polyubiquitination by the ankb f-box protein of Legionella pneumophila., William M. Bruckert

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Pathogenic role of acrolein in alcoholic liver disease., Wei-Yang (Jeremy) Chen

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Enzyme kinetics : 6-phosphofructo-2-kinase/2,6-bisphosphatase., Jennifer Clark

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SA-4-1BBL as a platform to develop adjuvant systems for prophylactic and therapeutic vaccines., Gunes Dinc 1984-

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Study of novel nanoparticle transport and drug release for cancer treatment., Christopher Gene England 1988-

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Neurodegeneration-associated instability of ribosomal DNA., Justin Lauren Hallgren 1981-

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The effect of spinal cord injury on vagal afferents., April N. Herrity

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Signaling mechanisms in regenerative myogenesis., Sajedah M. Hindi 1986-

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The role of stem cells in adipose tissue remodeling., Candice ReShay Holden 1988-

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The impact of inflammatory and immune response-related genetic variants on prostate cancer risk among men of African descent., Dominique Zilpha Jones

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A mechanism for trif adaptor-biased signaling by toll-like receptor 4., Joseph Peterson Kolb

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Functional implications of demyelination and the molecular control of remyelination in the adult mouse., Nicholas John Kuypers

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Biophysical and computational investigations into G-quadruplex structural polymorphism and interaction with small molecules., Huy Tuan Le

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Extracellular matrix proteins and the liver-lung axis in disease., Veronica L. Massey

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Development of models for the study of the molecular mechanisms of host restriction and adaptation of hantaviruses., Ryan Carroll McAllister 1988-

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BDNF maintains adult taste innervation and is required for taste nerve regeneration after injury., Lingbin Meng

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IL-12 induced modulation of tumor derived myeloid cell inflammatory responsiveness., Courtney Jetun Mitchell

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Post-transcriptional regulation of the Type IIA sodium-phosphate cotransporter by parathyroid hormone., Rebecca Dale Murray

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Epigenetic modifications associated with aortic remodeling in hyperhomocysteinemia., Nithya Narayanan

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Myocyte-specific overexpression of stromal cell-derived Factor 1 facilitates cardiac regeneration and improves myocardial function after infarction in mice., Detlef Ernst-Rudolf Obal

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Effects of step training on the kidneys following spinal cord injury in rats., Pradeepa Poudyal

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Bone strength and architecture : pharmacological targeting of CaMKK2 as a method for enhancing bone quality., Zachary James Pritchard

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Troglitazone suppresses glutamine metabolism and tumor cell growth through a ppar-independent mechanism., Miriam R. Reynolds 1965-

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Modulation of the ovarian cancer humoral response by tumor-derived exosomes., Carolyn Denise Roberson

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Genetic and mechanistic analysis of rat mammary cancer susceptibility., Jennifer Sanders

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The anti-obesogenic effects of nitric oxide., Brian Edward Sansbury 1985-

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Craniodental anatomy of a new late cretaceous multituberculate mammal from Udan Sayr, Mongolia., Amir Subhash Sheth

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Lunasin reduces the melanoma stem cell population in vitro and inhibits tumor proliferation in vivo., Christopher Paul Shidal

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Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death., Melissa Skibba 1990-

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Building a metabolic bridge between glycolysis and sphingolipid biosynthesis : implications in cancer., Morgan L. Stathem

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Inducible tumor difference between rapid and slow rat Nat2 congenic Fischer 344 rats administered methyl-nitrosourea., Marcus W. Stepp

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Effects of passive immobilization on locomotor recovery after spinal cord injury in adult rats., Kelsey Lee Stipp

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Evaluating the effects of aroclor 1260 in non-alcoholic fatty liver disease : the role of xenobiotic receptors., Banrida Wahlang

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Mechanisms of action and co-optive evolution for hypervariable courtship pheromones in plethodontid salamanders., Wilburn Beau Wilburn

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Inflammation-resolving lipid mediators promote revascularization to enhance wound healing., Michael Jingyuan Zhang

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Regulation of macrophage inflammatory signaling pathways by AMP-activated protein kinase., Yanfang Zhu

Theses/Dissertations from 2013

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Probing the anti-cancer mechanism of selenite : a metabolic approach., Alex Belshoff

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Mast cell-T cell interactions in inflammatory chemokine mediated immune surveillance of intestinal cancer., Sobha R. Bodduluri

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AMP-activated protein kinase regulation of myeloid antigen presenting cell activity., Kelly Casey Carroll

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Cyclin E induction and oncolytic replication of E1b-deleted adenoviruses., Pei-Hsin Cheng

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Genetic mapping and mechanism of action of rat mammary carcinoma susceptibility quantitative trait locus Mcs1b., Aaron D. denDekker

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Role of ethanol as a cofactor in HAART induced hepatic steatosis and injury., Hridgandh Donde

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Enhanced penetration of lipid functionalized nanoparticles in 3D cell cultures., Christopher Gene England 1988-

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Synapses, spines, zinc and pathology of Alzheimer's disease., Dmitry Familtsev 1985-

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The role of neurotrophin receptors in taste development., Da Fei

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The retina-prosthesis interface in two rat models of retinitis pigmentosa and functional changes associated with photoreceptor loss., James William Fransen

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Effects of telemetry EMG implants on hindlimb locomotor recovery in thoracic spinal contused rats., Matthew L. Hamilton

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Molecular bases of inherited bone marrow failures : Shwachman-Diamond syndrome and Diamond Blackfan anemia., Adrianna Lee Henson 1983-

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Gene expression analysis of neurotrophins, Trk receptors, and associated regulatory molecules after contusive spinal cord injury., Matthew Tyler Hougland 1982-

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Post-mortem analysis of cortical thickness and neuronal morphometry in autism., Shweta Sunil Kamat

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Audiovisual sensory processing in autism spectrum condition., Ryan Mikel Burdette Kiser

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6-phosphofructo-2-kinase inhibition induces autophagy as a survival mechanism., Alden Klarer

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Preclinical safety assessment of Griffithsin-based vaginal microbicides., Amanda Lasnik

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COUP-TFII and its interacting proteins in breast cancer and endocrine resistance., Lacey Morgan Litchfield

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Using the virtual world of Second Life to teach cultural competence for health science professional students., Ashley Mack 1986-

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Constructing the rod bipolar cell signalplex using animal models of retinal dysfunction., Thomas Andrew Ray 1986-

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Olanzapine-induced liver injury : direct metabolic effects, exacerbation by high-fat diet, and protection with sulforaphane., Robin H. Schmidt 1984-

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The role of a7 nicotine acetylcholine receptors in lung injury and repair., Glenn Vicary

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PACAP : a novel neuropeptide for pituitary gonadotroph maturation, function and regulation., Rongqiang Yang

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The involvement of beta-catenin in the inflammatory response leading to autoimmune diabetes development., Arin Lee Zirnheld

Theses/Dissertations from 2012

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Approaches in the treatment of Parkinson's disease : a focus on stem cell-based therapies., Tareq Al-maqtari 1979-

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Acetaldehyde dehydrogenase 2 (ALDH2) activation protects hepatocytes from mitochondrial damage and death caused by 4-hydroxynonenal., Keegan J. Baldauf 1982-

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Pivotal role of Interleukin-10 on microRNA-155 expression in regulation of the monocyte response in hypothermia., Adrian Theophil Billeter 1984-

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The dynamic equilibrium of human telomeric G-quadruplexes., Robert Buscaglia

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Gain and loss of functional locomotor recovery following contusive spinal cord injury in the adult rat., Krista Layne Caudle

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Morphological comparison of visual pathway projections to the temporal lobe from cortical area VI and the tectorecipient zone of the pulvinar nucleus in the tree shrew (Tupaia belangeri)., Donna Dillihay

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The role of endogenous Bcl-xL in regulation of apoptotic signaling pathways., Colins Ogwandi Eno 1982-

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Idiopathic pulmonary fibrosis : diagnosis, management, and the search for a cure., Daniel Fioret

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Development of pituitary tumor-transforming gene (PTTG) transgenic mice for the treatment of ovarian cancer., Miranda Y. Fong 1982-

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Role of human arylamine N-acetyltransferase in carcinogen metabolism and human breast cancer progression., Carmine Simone Leggett

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Co-option and adaptation of novel gene duplications for pheromone activity in a dusky salamander., Kari Anne Leichty 1987-

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Dysregulation of microRNA expression in acquired endocrine-resistant breast cancer., Tissa Thomas Manavalan

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Integrin inhibitor cycloRGDfV blunts enhanced LPS-induced liver injury caused by ethanol in mice., Veronica L. Massey

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Blockade of CXCR4 inhibits Porphyromonas gingivalis colonization in vivo and subsequent periodontal bone loss., Megan L. Mc Intosh

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Regulation of vascular smooth muscle cell phenotype., Joshua Kuimeta Salabei

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The regulation of RNA Polymerase I-mediated transcription in forebrain neurons., Scott Carl Smith

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Hyperhomocysteinemia alters sinoatrial and atrioventricular nodal function : role of the cardiac NMDA receptor., Chirag V. Soni

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Expression of adipocyte/macrophage fatty acid binding protein promotes tumor growth and metastasis., Ashley Simone Triplett

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Polychlorinated biphenyl 153 exacerbates nonalcoholic fatty liver disease in C57BL/6 mice., Banrida Wahlang 1986-

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Structure-activity relationship model for estrogen receptor ligands., Huihui Wu 1979-

Theses/Dissertations from 2011

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Roles of 5HT1A receptor in CNS neurogenesis and ADAM21 in spinal cord injury., Sheila Ann Arnold 1981-

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Roles of VAMP3 in melanoma cell migration and integrin trafficking., Yaman Babi 1981-

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Development and evaluation of polymeric implants of curcumin for enhanced chemopreventive activity., Shyam Sunder Bansal

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Partial vs. full support of the heart with a continuous-flow left ventricular assist device : implications for myocardial recovery., Carlo Renato G. Bartoli

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Profile of systemic treatment with the antiviral lectin Griffithsin in guinea pigs., Christopher Lynn Barton 1976-

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Mechanistic insights into copper-induced regression of heart hypertrophy., Katherine Bourcy

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Identification and biochemical characterization of the CHLAMYDIA TRACHOMATIS type III secretion chaperone, SLC1, and its role in the translocation of the invasion-associated effector TARP., Amanda J. Brinkworth

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Prevention and treatment of lung cancer by green tea polyphenols., Pengxiao Cao