This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2023

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Supraspinal reorganization after pediatric-onset spinal cord injury., Luis Alvarado

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Connectivity of amygdala somatostatin-expressing neurons and their role in taste-guided behavior., Jane Jeruto Bartonjo

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Investigating the effects of subchronic dietary zinc supplementation on diet-induced metabolic dysfunction-associated steatotic liver disease., Oluwanifemi Esther Bolatimi

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Study of the effects of chronic cadmium exposure on the pathogenesis of pulmonary arterial hypertension., Dakotah Dominique Cathey

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New species of dryolestoid from the late cretaceous allen formation and implications for South American faunal diversity., Brigid Erin Connelly

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Perineuronal nets are not required to close the critical period for ocular dominance plasticity., Emily Crouse

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Novel insights into oligodendrocyte biology from developmental myelination studies in autophagy deficient mice and analysis of oligodendrocyte translatome response to contusive spinal cord injury., Michael David Forston

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Swallow, breathing and survival: sex-specific effects of opioids., Michael Frazure

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Chemosensory processing by the mediodorsal thalamus., Kelly Fredericksen

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Characterization of the immunoglobulin lambda chain across diverse human populations., William Gibson

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Environmental exposures and aging., Daniel Chris Gomes

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The impact of environmental pollutants on alcohol-associated liver disease pathogenesis., Tyler Charles Gripshover

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KDM5B as a potential epigenetic regulator of cardiomyocyte regeneration and cell cycle activation., Dana Hammouri

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Inhibition of RAS as a novel therapeutic approach in Luminal B breast cancer., Raphael Ngozichi Jigo

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The role of e-liquid constituents in e-cigarette-induced cardiac arrhythmia and autonomic imbalance., Cory Kucera

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The alphaviral capsid protein inhibits IRAK1-dependent TLR signaling to promote pathogenesis., V. "Trey" Landers

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Lung cancer-kidney crosstalk enhances cisplatin-induced nephrotoxicity., Andrew Orwick

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Epitranscriptomic regulation in breast cancer and PCB-induced liver disease., Belinda Petri

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Identification of a role beyond iron acquisition for yersiniabactin during Yersinia pestis infection., Sarah Price

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Epicertin: preclinical development of a novel mucosal healing agent for ulcerative colitis., Micaela Reeves

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Aurka inhibition-based combination therapy approaches in glioblastoma., Muge Sak

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The interplay between lung adenocarcinoma, nutrient availability, and the microbiome., Alexis A. Vega

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Using a toxic aging coin to assess hexavalent chromium-induced neurotoxicity., Samuel Thomas Vielee

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Investigation of heterocyclic amines and N-acetyltransferase 2 genetic polymorphism in the dysregulation of hepatic energy homeostasis: A gene-environment approach., Kennedy M Walls

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Soluble epoxide hydrolase inhibition: a novel therapeutic strategy for alcohol-associated liver disease., Jeffrey Warner

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An investigation into structural plasticity in peripheral taste neurons associated with taste cell turnover., Zachary Whiddon

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Synaptic properties of parabigeminal circuits., Kyle Whyland

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Ethanol dysregulates Sirt1-mediated lipogenic signaling pathways through α4*-nicotinic acetylcholine receptors in hepatocytes., Caitlin Christina Wilkerson

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Irreversible electroporation potentiates beta glucan induced trained innate immunity: a novel combination treatment for pancreatic adenocarcinoma., Matthew Woeste

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Illuminating underappreciated mechanisms of receptor regulation in human lymphocytes., Cassandra Woolley

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Toward a comprehensive account of orientation selectivity in the retina., Megan Zipperer

Theses/Dissertations from 2022

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The impact of volume of tissue activation on cortical-striatal networks and verbal fluency declines in post-deep brain stimulation Parkinson's disease patients., Alexander Luke Alley

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The effect of telepractice on vocal interaction between provider, deaf and hard-of-hearing pediatric patients, and caregivers., Abigail Betts

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Adipose-derived stromal vascular fraction therapy improves age-related adrenergic mediated microvascular dysfunction and increases revascularization potential following injury., Gabrielle Brown

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Defining the impact of clinically modeled hindlimb stretching, exercise, & inactivity on functional recovery after spinal cord injury., Greta Cesarz

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Targeting pathological changes in the gut protects the CNS from neuropathology., Benjamin Tyler Charpentier

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Applications of nuclear magnetic resonance spectroscopy: from drug discovery to protein structure and dynamics., Mark Vincent C. dela Cerna

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The impact of PEGylation on cellular uptake and in vivo biodistribution of gold nanoparticle MRI contrast agents., Nagwa El-Baz

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Metabolic foundations of exercise-induced cardiac growth., Kyle Fulghum

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Investigation of human n-acetyltransferases (NAT1 and NAT2) genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity., Mariam Habil

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Critical thinking or critical creativity: applying De Bono's six thinking hats to speech-language pathology education and practice., Samantha Hahn

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Etracellular vesicles from lactobacillus rhamnosus GG protect against alcohol-induced liver injury through suppression of intestinal MIR 194 and subsequent activation of FXR in mice., Mengwei Jiang

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Understanding neuroanatomy in a virtual 3D environment: creation and use of a new survey tool to evaluate the effectiveness of 3D software in neuroanatomy education for understanding superficial and deep brain structures., Akash Khare

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Genomic tools and models for investigating the role of germline diversity in mouse antibody repertoire development., Justin T. Kos

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Translating particulate hexavalent chromium-induced chromosome instability from human lung cells to experimental animals, human lung tumors and whale cells., Haiyan Lu

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The effect of volatile organic compounds on endothelial function and atherogenesis., Samantha McFall

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A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller

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Aggregatibacter actinomycetemcomitans exploits and modulates the immune response by human neutrophils for survival in the anaerobic environment., Hazel Ozuna

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Voltage-gated potassium channel dependent mechanisms of cardiovascular adaptation to chronic exercise., Sean Raph

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Tobacco-derived aldehydes, platelets, and thrombogenicity: role of transient receptor potential ankyrin-1., Andre D. Richardson

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The role of obesity in macrophage-mediated mechanisms promoting early-onset colon cancer., Katharina Marietta Scheurlen

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Induction of trained immunity by particulate β-glucan controls cancer metastasis through the sphingolipids-mediated mitochondrial fission pathway., Rejeena Shrestha

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Cannabinoids and retinal fibrotic disorders., Lucy June Sloan

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Cadence and range of motion modulate pedal force in a rat model of motorized cycling after spinal cord injury., Gregory States

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HGF-mediated c-met signaling in human corneal epithelial cells., Kate Tarvestad

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The impact of volatile organic compound exposure on subclinical biomarkers of cardiovascular injury., Breandon Taylor

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Molecular mechanisms of hexavalent chromium-induced centrosome amplification., Jennifer Haruka Toyoda

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Stromal vascular fraction restores vasodilatory function by reversing mitochondrial dysfunction and oxidative stress in aging-induced coronary microvascular disease., Evan Paul Tracy

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Lysosomal evasion of legionella pneumophilia the effector., Bethany Vaughn

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Defining the importance of the hnRNP I interaction to the Sindbis virus subgenomic viral RNA using an innovative tethering approach., Claire Westcott

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The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt

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Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams

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Examining the effects of NPRA antagonist anantin on sci-induced ployuria., Lindsey Zipperer

Theses/Dissertations from 2021

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Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload., Timothy N. Audam

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Anxiety and self-efficacy related to learning neuroanatomy in an integrated medical curriculum., Jessica S. Bergden

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Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis., Rumeysa Biyik-Sit

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Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri

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Effects of chemosensory experience and context on consummatory behaviors., Saphira M. Chiu

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Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent

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Genetic and functional analysis of rat mammary cancer susceptibility., Emily L Duderstadt

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Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism., Marc Matthew Dwenger

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PDE4 inhibition: a novel therapeutic strategy in liver fibrosis., Mohamed Elnagdy

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Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control., Anne Elena Geller

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Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model., Tyler Charles Gripshover

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Investigations of potential mechanisms underlying spinal cord injury-induced polyuria., Jason H. Gumbel

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Sex-based differences in microbiota composition and metabolomic profiles associated with altered macrophage function and protection from lupus in BWF1 mice., James William Harder

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The role of sphingolipids in AKI and the progression to CKD: potential therapuetic targets., Nicholas A. Hoffman

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Assessing the role of chronic arsenite exposure in disrupting the EGFR signaling axis., Christine Kim

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The role of Src in NSCLC cell and lung fibroblast migration on 3D cell-derived matrix., Austin M Krueger

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The importance of noncapped viral genomic RNA to alphaviral infection and pathogenesis., Autumn LaPointe

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Assessing the role of arsenic exposure and MIRNA-186 in skin tumorigenesis and chromosomal instability., Angeliki Lykoudi

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Translating particulate hexavalent chomium-induced chromosome instability, loss of homologous recombination repair and targeting of RAD51 from human lung fibroblasts to human bronchial epithelial cells., Idoia Meaza Isusi

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Q-Griffithsin interactions and utility for the prevention and treatment of Mucosal infections., Henry Nabeta

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Metabolic-epigenetic regulation of macrophage polarization., Jordan T. Noe

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An analysis of taste neuron morphological variability: influences of neuron type and plasticity., Lisa Christina Ohman

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Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury., Andrew Joseph Orwick

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Role of KVβ2 subunits in regulation of resistance arterial tone., Sean M Raph

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Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis., Micaela Ann Reeves

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Characterizing the role of macrophages in cisplatin-induced kidney injury and progression to chronic kidney disease., Sophia M. Sears

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Determination of the biological functions of undefined domains of VEEV nsP2., Andrew Michael Skidmore

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Role of meibum and tear phospholipids in the evaporative water loss associated with dry eye., Samiyyah M. Sledge

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Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance., Kennedy M. Walls

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Oligodendrocyte responses after spinal cord injury., George Zach Wei

Theses/Dissertations from 2020

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Factors of dysphagia in the overdose population post extubation., Renee Brown

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Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle

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Formation, organization, and synaptic properties of circuits between thalamic reticular nucleus and dorsal lateral geniculate nucleus., Peter W. Campbell

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The retinoblastoma protein mediates metabolic reprogramming in lung cancer., Lindsey R. Conroy

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Autism Spectrum Disorder: investigating predictive adaptive behavior skill deficits in young children., Emma L. Feige

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N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil

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Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules., Christopher Lynn Harding