This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.
Theses/Dissertations from 2022
The impact of volume of tissue activation on cortical-striatal networks and verbal fluency declines in post-deep brain stimulation Parkinson's disease patients., Alexander Luke Alley
The effect of telepractice on vocal interaction between provider, deaf and hard-of-hearing pediatric patients, and caregivers., Abigail Betts
Defining the impact of clinically modeled hindlimb stretching, exercise, & inactivity on functional recovery after spinal cord injury., Greta M. Cesarz
Targeting pathological changes in the gut protects the CNS from neuropathology., Benjamin Tyler Charpentier
Applications of nuclear magnetic resonance spectroscopy: from drug discovery to protein structure and dynamics., Mark Vincent C. dela Cerna
The impact of PEGylation on cellular uptake and in vivo biodistribution of gold nanoparticle MRI contrast agents., Nagwa El-Baz
Metabolic foundations of exercise-induced cardiac growth., Kyle Levi Fulghum
Investigation of human n-acetyltransferases (NAT1 and NAT2) genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity., Mariam Refaat Zaky Habil
Critical thinking or critical creativity: applying De Bono's six thinking hats to speech-language pathology education and practice., Samantha Hahn
Genomic tools and models for investigating the role of germline diversity in mouse antibody repertoire development., Justin T. Kos
The effect of volatile organic compounds on endothelial function and atherogenesis., Samantha Ann McFall
A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller
Tobacco-derived aldehydes, platelets, and thrombogenicity: role of transient receptor potential ankyrin-1., Andre D. Richardson
The role of obesity in macrophage-mediated mechanisms promoting early-onset colon cancer., Katharina Marietta Scheurlen
Induction of trained immunity by particulate β-glucan controls cancer metastasis through the sphingolipids-mediated mitochondrial fission pathway., Rejeena Shrestha
Cannabinoids and retinal fibrotic disorders., Lucy June Sloan
Cadence and range of motion modulate pedal force in a rat model of motorized cycling after spinal cord injury., Gregory J.R. States
HGF-mediated c-met signaling in human corneal epithelial cells., Kate Elise Tarvestad
The impact of volatile organic compound exposure on subclinical biomarkers of cardiovascular injury., Breandon Scot Taylor
Molecular mechanisms of hexavalent chromium-induced centrosome amplification., Jennifer Haruka Toyoda
Lysosomal evasion of legionella pneumophilia the effector., Bethany Vaughn
Defining the importance of the hnRNP I interaction to the Sindbis virus subgenomic viral RNA using an innovative tethering approach., Claire Westcott
The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt
Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams
Examining the effects of NPRA antagonist anantin on sci-induced ployuria., Lindsey Elaine Zipperer
Theses/Dissertations from 2021
Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload., Timothy N. Audam
Anxiety and self-efficacy related to learning neuroanatomy in an integrated medical curriculum., Jessica S. Bergden
Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis., Rumeysa Biyik-Sit
Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri
Effects of chemosensory experience and context on consummatory behaviors., Saphira M. Chiu
Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent
Genetic and functional analysis of rat mammary cancer susceptibility., Emily L Duderstadt
Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism., Marc Matthew Dwenger
PDE4 inhibition: a novel therapeutic strategy in liver fibrosis., Mohamed Elnagdy
Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control., Anne Elena Geller
Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model., Tyler Charles Gripshover
Investigations of potential mechanisms underlying spinal cord injury-induced polyuria., Jason H. Gumbel
Sex-based differences in microbiota composition and metabolomic profiles associated with altered macrophage function and protection from lupus in BWF1 mice., James William Harder
The role of sphingolipids in AKI and the progression to CKD: potential therapuetic targets., Nicholas A. Hoffman
Assessing the role of chronic arsenite exposure in disrupting the EGFR signaling axis., Christine Kim
The role of Src in NSCLC cell and lung fibroblast migration on 3D cell-derived matrix., Austin M Krueger
The importance of noncapped viral genomic RNA to alphaviral infection and pathogenesis., Autumn LaPointe
Assessing the role of arsenic exposure and MIRNA-186 in skin tumorigenesis and chromosomal instability., Angeliki Lykoudi
Q-Griffithsin interactions and utility for the prevention and treatment of Mucosal infections., Henry Nabeta
Metabolic-epigenetic regulation of macrophage polarization., Jordan T. Noe
An analysis of taste neuron morphological variability: influences of neuron type and plasticity., Lisa Christina Ohman
Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury., Andrew Joseph Orwick
Role of KVβ2 subunits in regulation of resistance arterial tone., Sean M Raph
Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis., Micaela Ann Reeves
Characterizing the role of macrophages in cisplatin-induced kidney injury and progression to chronic kidney disease., Sophia M. Sears
Determination of the biological functions of undefined domains of VEEV nsP2., Andrew Michael Skidmore
Role of meibum and tear phospholipids in the evaporative water loss associated with dry eye., Samiyyah M. Sledge
Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance., Kennedy M. Walls
Oligodendrocyte responses after spinal cord injury., George Zach Wei
Theses/Dissertations from 2020
Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle
Formation, organization, and synaptic properties of circuits between thalamic reticular nucleus and dorsal lateral geniculate nucleus., Peter W. Campbell
The retinoblastoma protein mediates metabolic reprogramming in lung cancer., Lindsey R. Conroy
Autism Spectrum Disorder: investigating predictive adaptive behavior skill deficits in young children., Emma L. Feige
N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil
Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules., Christopher Lynn Harding
A novel role for RASSF1A in the regulation of RAS activation., Desmond Ramón Harrell Stewart
Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis., Dylan MacGregor Johnson
Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li
Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch
Hearing loss: investigating the comfort, confidence, knowledge, and preparedness of Kentucky school-based speech-language pathologists., Amanda Matsumoto
Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng
The emerging oral pathogen, filifactor alocis, disrupts neutrophil functions to enhance survival and dysregulate inflammation., Irina Miralda Molina
Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems., Robert Chandos Monsen
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through NF-Kβ dependent glycolytic metabolic reprogramming., Samantha M. Morrissey
Modulation of inflammatory pathway by inflammatory inhibitor JSH-23 mitigates diabetic retinopathy., Rubens Petit Homme
Modulation of host innate immune cells by Yersinia pestis to create a permissive environment for replication., Amanda Rose Pulsifer
Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson
Identification and structural characterization functional motifs in the Porphyromonas gingivalis MFA1 short fimbria., Mohammad K. Roky
Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses., Pradeep Shrestha
Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer
Tissue-resident myeloid-derived suppressor cells modulate immune homeostasis in healthy adipose., Katlin Brooke Stivers
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner
The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young
Theses/Dissertations from 2019
A distinct pattern of sterile inflammation induced by zinc oxide nanowires., Ruqaih Salem Alghsham
Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent
Understanding object motion encoding in the mammalian retina., Victor Julian DePiero
Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin
Inspiratory muscle recruitment during swallow and a comparison across airway behaviors., Allison V. English
Alterations in rhythmic licking behaviors following fibrosis in the rat mylohyoid muscle., Brittany Fletcher
Coordination of airway protective behaviors and swallow: effects of afferent feedback and sex., Alyssa D. Huff
The effects of nicotine and cigarette smoking on cardiac electrophysiology., Affan B. Irfan
Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga
