This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.
Theses/Dissertations from 2025
Advancing research on Retinitis Pigmentosa: An investigation of natural history, visual system plasticity, and mutation-independent treatment., Cecilia A. Attaway
SARS-CoV-2 modulates PLA2G2D/PGD2 signaling to manipulate host immune response to increase disease severity., Dante L. Hamiel
The dynamic role of hyaluronan in acute cardiac wound healing., Danielle T. Little
The role of TGFβ-activated kinase 1 in fibroblast differentiation and cardiac remodeling after injury., Daniel Chien Nguyen
CNS-specific HIV reservoir characterization in humans: advancing our understanding through novel genomics methods., Ghazal Sadri
The effects of ethanol and tributyrin on Alzheimer's disease pathogenesis in 3×Tg-AD mice., Lucy June Sloan
Long-term changes in bolus parameters during swallowing post-chemoradiation treatment., Brittany Rebecca Smiley
Advancing speech intelligibility assessment: Comparing school-based speech-language pathologists, laypersons, and speech recognition software., Hannah Stewart
Volatile organic compounds and their relation to sympathetic activation and autonomic balance in humans., Cameron Kyle Stopforth
Theses/Dissertations from 2024
The role of matrix metalloproteinase-9 gene ablation in preserving ejection fraction during chronic volume overload-induced heart failure., Oluwaseun Ebenezer Akinterinwa
Inhibition of pro-inflammatory lipid mediators by Yersinia pestis., Amanda Brady
Regulation and mechanisms of ocular dominance plasticity at cellular resolution., Thomas Christopher Brown
Proteolytic manipulation of neutrophil responses and the efferocytic synapse by porphyromonas gingivalis., Kelley N. Cooper
Dementia of the Alzheimer’s type in adults with Down syndrome: knowledge among graduate students in physical therapy, occupational therapy, and speech-language pathology., Abigail Regan Donaway
Impact of human immunoglobulin genetic variants on the expressed antibody repertoire., Eric Engelbrecht
Unraveling the complex dynamics of cardiac fibrosis: CCN1 as a novel regulator of scar collagen architecture and structural integrity in myocardial infarction., Annalara Garland Fischer
Uncovering the hidden diversity of antibody heavy chains and their implications for autoantibody mediated disease., Easton Earl Ford
Differential responses of human neutrophils to legionella species., Hannah E. Hanford
Preclinical stability assessment of EPICERTIN, a biotherapeutic candidate for ulcerative colitis mucosal healing., Wendy Michelle Kittle
Macrophage polarization and colorectal cancer immune checkpoint protein expression., Anne Macleod
Investigation of Avaren-Fc's therapeutic potential against ovarian cancer., Katarina Lee Mayer
Exosomal cannabidiol: A promising candidate for targeted oral delivery against breast cancer., Disha Nagesh Moholkar
Establishing a mouse model of cerebral/cortical visual impairment., Dana K. Oakes
Molecular mechanisms of exercise-stimulated resolution of inflammation and its dietary dependence., Ernesto H. Pena Calderin
A mixed methods investigation of first-year medical students' competency development in the gross anatomy laboratory context., Emily M. Porta-Miller
Plasma resuscitation attenuates hemorrhage-induced glomerular barrier damage and dysfunction., William Byron Risinger
Porphyromonas gingivalis inactivates anti-viral immunity at the oral and respiratory epithelium., Carlos J. Rodriguez Hernandez
Tongue-tie: Impact on oropharyngeal function during swallow., Kolbie A. Vincent
Theses/Dissertations from 2023
Effects of environmental pollutants on liver disease: role of the gut-liver axis., Ngozi Victoria Adiele
Supraspinal reorganization after pediatric-onset spinal cord injury., Luis Alvarado
Connectivity of amygdala somatostatin-expressing neurons and their role in taste-guided behavior., Jane Jeruto Bartonjo
Investigating the effects of subchronic dietary zinc supplementation on diet-induced metabolic dysfunction-associated steatotic liver disease., Oluwanifemi Esther Bolatimi
Study of the effects of chronic cadmium exposure on the pathogenesis of pulmonary arterial hypertension., Dakotah Dominique Cathey
New species of dryolestoid from the late cretaceous allen formation and implications for South American faunal diversity., Brigid Erin Connelly
Perineuronal nets are not required to close the critical period for ocular dominance plasticity., Emily Crouse
Novel insights into oligodendrocyte biology from developmental myelination studies in autophagy deficient mice and analysis of oligodendrocyte translatome response to contusive spinal cord injury., Michael David Forston
Swallow, breathing and survival: sex-specific effects of opioids., Michael Frazure
Chemosensory processing by the mediodorsal thalamus., Kelly Fredericksen
Characterization of the immunoglobulin lambda chain across diverse human populations., William Gibson
Environmental exposures and aging., Daniel Chris Gomes
The impact of environmental pollutants on alcohol-associated liver disease pathogenesis., Tyler Charles Gripshover
KDM5B as a potential epigenetic regulator of cardiomyocyte regeneration and cell cycle activation., Dana Hammouri
Inhibition of RAS as a novel therapeutic approach in Luminal B breast cancer., Raphael Ngozichi Jigo
The role of e-liquid constituents in e-cigarette-induced cardiac arrhythmia and autonomic imbalance., Cory Kucera
The alphaviral capsid protein inhibits IRAK1-dependent TLR signaling to promote pathogenesis., V. "Trey" Landers
Lung cancer-kidney crosstalk enhances cisplatin-induced nephrotoxicity., Andrew Orwick
Epitranscriptomic regulation in breast cancer and PCB-induced liver disease., Belinda Petri
Identification of a role beyond iron acquisition for yersiniabactin during Yersinia pestis infection., Sarah Price
Epicertin: preclinical development of a novel mucosal healing agent for ulcerative colitis., Micaela Reeves
Aurka inhibition-based combination therapy approaches in glioblastoma., Muge Sak
The interplay between lung adenocarcinoma, nutrient availability, and the microbiome., Alexis A. Vega
Using a toxic aging coin to assess hexavalent chromium-induced neurotoxicity., Samuel Thomas Vielee
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy for alcohol-associated liver disease., Jeffrey Warner
An investigation into structural plasticity in peripheral taste neurons associated with taste cell turnover., Zachary Whiddon
Synaptic properties of parabigeminal circuits., Kyle Whyland
Ethanol dysregulates Sirt1-mediated lipogenic signaling pathways through α4*-nicotinic acetylcholine receptors in hepatocytes., Caitlin Christina Wilkerson
Illuminating underappreciated mechanisms of receptor regulation in human lymphocytes., Cassandra Woolley
Toward a comprehensive account of orientation selectivity in the retina., Megan Zipperer
Theses/Dissertations from 2022
The impact of volume of tissue activation on cortical-striatal networks and verbal fluency declines in post-deep brain stimulation Parkinson's disease patients., Alexander Luke Alley
The effect of telepractice on vocal interaction between provider, deaf and hard-of-hearing pediatric patients, and caregivers., Abigail Betts
Targeting pathological changes in the gut protects the CNS from neuropathology., Benjamin Tyler Charpentier
Applications of nuclear magnetic resonance spectroscopy: from drug discovery to protein structure and dynamics., Mark Vincent C. dela Cerna
The impact of PEGylation on cellular uptake and in vivo biodistribution of gold nanoparticle MRI contrast agents., Nagwa El-Baz
Metabolic foundations of exercise-induced cardiac growth., Kyle Fulghum
Critical thinking or critical creativity: applying De Bono's six thinking hats to speech-language pathology education and practice., Samantha Hahn
Genomic tools and models for investigating the role of germline diversity in mouse antibody repertoire development., Justin T. Kos
The effect of volatile organic compounds on endothelial function and atherogenesis., Samantha McFall
A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller
Tobacco-derived aldehydes, platelets, and thrombogenicity: role of transient receptor potential ankyrin-1., Andre D. Richardson
The role of obesity in macrophage-mediated mechanisms promoting early-onset colon cancer., Katharina Marietta Scheurlen
Induction of trained immunity by particulate β-glucan controls cancer metastasis through the sphingolipids-mediated mitochondrial fission pathway., Rejeena Shrestha
Cannabinoids and retinal fibrotic disorders., Lucy June Sloan
Cadence and range of motion modulate pedal force in a rat model of motorized cycling after spinal cord injury., Gregory States
HGF-mediated c-met signaling in human corneal epithelial cells., Kate Tarvestad
The impact of volatile organic compound exposure on subclinical biomarkers of cardiovascular injury., Breandon Taylor
Molecular mechanisms of hexavalent chromium-induced centrosome amplification., Jennifer Haruka Toyoda
Lysosomal evasion of legionella pneumophilia the effector., Bethany Vaughn
Defining the importance of the hnRNP I interaction to the Sindbis virus subgenomic viral RNA using an innovative tethering approach., Claire Westcott
The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt
Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams
Examining the effects of NPRA antagonist anantin on sci-induced ployuria., Lindsey Zipperer
Theses/Dissertations from 2021
Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload., Timothy N. Audam
Anxiety and self-efficacy related to learning neuroanatomy in an integrated medical curriculum., Jessica S. Bergden
Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis., Rumeysa Biyik-Sit
Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri
Effects of chemosensory experience and context on consummatory behaviors., Saphira M. Chiu
Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent
