This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2020

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Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle

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Formation, organization, and synaptic properties of circuits between thalamic reticular nucleus and dorsal lateral geniculate nucleus., Peter W. Campbell

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The retinoblastoma protein mediates metabolic reprogramming in lung cancer., Lindsey R. Conroy

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Autism Spectrum Disorder: investigating predictive adaptive behavior skill deficits in young children., Emma L. Feige

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N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil

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Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules., Christopher Lynn Harding

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A novel role for RASSF1A in the regulation of RAS activation., Desmond Ramón Harrell Stewart

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Evaluating the effects of PCBs in non-alcoholic fatty liver disease & diabetes and the role of AhR in regulating the hepatic proteome and lipid metabolism., Jian Jin

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The cardiovascular effects of tobacco product-derived aldehydes: contribution of transient receptor potential ankyrin-1., Lexiao Jin

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Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis., Dylan MacGregor Johnson

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Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li

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Sulforaphane protects against ethanol-induced apoptosis and teratogenesis through epigenetic modulation of anti-apoptotic genes., Yihong Li

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Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch

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Hearing loss: investigating the comfort, confidence, knowledge, and preparedness of Kentucky school-based speech-language pathologists., Amanda Matsumoto

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Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng

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The emerging oral pathogen, filifactor alocis, disrupts neutrophil functions to enhance survival and dysregulate inflammation., Irina Miralda Molina

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Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems., Robert Chandos Monsen

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Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through NF-Kβ dependent glycolytic metabolic reprogramming., Samantha M. Morrissey

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Modulation of inflammatory pathway by inflammatory inhibitor JSH-33 mitigates diabetic retinopathy., Rubens Petit Homme

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Modulation of host innate immune cells by Yersinia pestis to create a permissive environment for replication., Amanda Rose Pulsifer

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Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson

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Identification and structural characterization functional motifs in the Porphyromonas gingivalis MFA1 short fimbria., Mohammad K. Roky

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Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses., Pradeep Shrestha

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Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer

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Tissue-resident myeloid-derived suppressor cells modulate immune homeostasis in healthy adipose., Katlin Brooke Stivers

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Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner

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The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young

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The role of Slc7a11 in controlling extracellular and intracellular redox environments of lung fibroblasts - potential targets for intervention in aging and idiopathic pulmonary fibrosis., Yuxuan Zheng

Theses/Dissertations from 2019

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A distinct pattern of sterile inflammation induced by zinc oxide nanowires., Ruqaih Salem Alghsham

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Characterization of a more clinically relevant human leukemia xenograft model to examine perturbation of MET/SAM metabolism as a novel therapeutic paradigm for MLL-R leukemia in vivo., Aditya Barve

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Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent

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Understanding object motion encoding in the mammalian retina., Victor Julian DePiero

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Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin

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Inspiratory muscle recruitment during swallow and a comparison across airway behaviors., Allison V. English

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Alterations in rhythmic licking behaviors following fibrosis in the rat mylohyoid muscle., Brittany Fletcher

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Coordination of airway protective behaviors and swallow: effects of afferent feedback and sex., Alyssa D. Huff

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The effects of nicotine and cigarette smoking on cardiac electrophysiology., Affan B. Irfan

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Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga

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Development of BAR-peptide nanoparticles and electrospun fibers for the prevention and treatment of oral biofilms., Mohamed Yehia Mahmoud

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Preference for odor-taste mixtures is dependent on previous experience., Kelsey Allison McQueen

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Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression., Stephanie Metcalf

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The identification of long non-coding RNA ZFAS1 through an exploratory RNA-sequencing analysis and its association with epithelial-to-mesenchymal transition in colon cancer adenocarcinoma., Stephen J. O'Brien

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Glycine receptor expression across identified retinal ganglion cell types., Ian Scot Pyle

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A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease., Joshua Mark Royal

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Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system., Douglas John Owulaku Saforo

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Investigating predictive relationships between speech-language pathology graduate students' sense of classroom community, perceived learning, and perceived anxiety., Emily B. Schantz

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Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury., Sophia M. Sears

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The self-efficacy of biological mothers and foster mothers caring for infants prenatally exposed to drugs or treated for NAS : examination of potentially influencing factors., Megan Kathleen Sherehiy

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The effect of spinal cord injury on sexual function., Casey J. Steadman

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Electrospun fibers and nanoparticles for the prevention of sexually transmitted infections., Kevin Michael Tyo

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The manipulation of host transcription by the ANKH effector of legionella., Juanita E. Von Dwingelo

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Paraoxonase 2 is critical for non-small cell lung carcinoma proliferation., Aaron Whitt

Theses/Dissertations from 2018

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Nutritional virulence of Legionella pneumophila., Ashley M. Best

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Combination oral immunotherapy with IL-10 and IL-12 effectively treats colon tumors via synergistic effects on IL-17 producing T cells and colon epithelial barrier integrity., Neal Bhutiani

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Unfolded protein response pathways in skeletal muscle homeostasis., Kyle R. Bohnert

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Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach., Samantha Marie Carlisle

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The migration and developmental remodeling of intrinsic interneurons in visual thalamus and the role of retinal signaling., Naomi E. Charalambakis

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The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet., Liya Chen

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Functional and structural impact of the loss of the leucine-rich repeat protein LRIT1 in the mouse retina., Catherine Ann Cobb

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CD11b regulation of B cell receptor signaling in health and systemic lupus erythematosus., Paul Lorenzo Dascani

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Characterizing the gut microbiota during plasmodium infection and antimalarial treatment., Joshua E. Denny

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Maturation of human induced pluripotent stem cell derived engineered cardiac tissues using chief transfection and chronic optical pacing., Marc M. Dwenger

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A cancer-targeted gold nanoparticle-based MRI contrast agent., Nagwa El-Baz

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The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation., Jon David Faughn

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Traumatic brain injury : investigating misconceptions among graduate students in physical therapy, occupational therapy, and speech-language pathology., Michael Frazure

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EGFR signaling from the early endosome., Julie A. Gosney

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Epidermal growth factor receptor (EGFR) inhibition by polychlorinated biphenyls contributes to non-alcoholic fatty liver disease (NAFLD)., Josiah Hardesty

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Inflammasome independent leukotriene-b4 production drives crystalline silica induced sterile inflammation., Bindu Hegde

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Autism spectrum disorder : investigating predictive diagnostic relationships in children three years-of-age and younger., Kaitlin Juergensen

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Swallow and breathing coordination following suprahyoid muscle injury., Bradley Kimbel

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Assessing the role of arsenite in disrupting the EGFR signaling axis., Christine Kim

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Vinyl chloride enhances diet-induced liver injury via metabolic dyshomeostasis : critical role of mitochondria., Anna L. Lang

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A study of GPR3, GPR6, of GPR12 as novel molecular targets for cannabidiol., Alyssa S. Laun

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A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes., Qian Lin

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Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy., Avisek Majumder

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Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age., Ryan Carroll McAllister

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A new surgical approach for O-C2 fusion, solving the problem of dysphagia., M. Kathryn McClure

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Evaluation of drug-loaded gold nanoparticle cytotoxicity as a function of tumor tissue heterogeneity., Hunter Allan Miller

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Influence of bilberry-derived anthocyanidins on key regulators of colorectal cancer development., Ashley M. Mudd

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Alpha-amino methylation and acetylation are novel regulators of MYL9 function., Christopher David Nevitt

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Cholesterol metabolism and statin effects on an FH class II LDL-receptor mutation., Linda Omer

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Wnt/β-Catenin mediated cancer stem cell activation in hepatocellular carcinoma., Harshulkumar M. Pandit

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Divergent evolution of di-lysine ER retention vs. farnesylation motif-mediated anchoring of the ankb virulence effector., John David Perpich

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Role of TrkB-signaling in taste development and function., Jennifer Rios-Pilier

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Therapeutic potential of a plant-made cholera toxin b subunit variant for the treatment of ulcerative colitis., Joshua Mark Royal

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Epidermal growth factor-like ligands regulate dimer selection., Jamie S. Rush

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Characterization of type II toxin anti-toxin systems in Aggregatibacter actinomycetemcomitans., Blair W. Schneider

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Feeding behaviors and the child with posterior tongue-tie : comparison to norms., McKenzie Sexton

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A clinically relevant mouse model of cisplatin-induced kidney injury., Cierra Nichole Sharp

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Investigating the impact of NRMT1 cancer mutants on catalytic specificity and the DNA damage response., Kaitlyn Marie Shields

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The effects of polychlorinated biphenyls exposure on non-alcoholic fatty liver disease : role of aryl hydrocarbon receptor., Hongxue Shi

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Organization and development of cholinergic input to the mouse visual thalamus., Guela Sokhadze

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Canonical nuclear factor-κB signaling in satellite stem cell homeostasis and function., Alex R. Straughn

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Exercise preconditioning and TFAM overexpression diminish skeletal muscle atrophy., Nicholas Todd Theilen

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Particulate hexavalent chromium does not induce centrosome amplification in sperm whale and bowhead whale cells., Jennifer Haruka Toyoda

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Characterizing the virulence factor YapE in Yersinia pestis., Tiva Templeton VanCleave

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Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity., Alexis Avidan Vega

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The involvement of epithelial cells in arenavirus-induced pathogenesis., Nikole Leslie Margaret Warner

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A model to study the effects of whole life chronic exposure to arsenic or cadmium on the development of adult metabolic syndrome : initial characterization of hepatic changes., Jamie L. Young

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Tissue engineered micro and macrovasculature utilizing stromal vascular fraction., Joseph Samir Zakhari